Synthesis of New Aryl(Hetaryl)-Substituted Tandospirones Under Reductive Heck Type Hydroarylations and Isoxazoline Derivatives via 1,3-Dipolar Cycloaddition Reactions with Expected Anxiolytic Activity

Kulu, Irem; Kopruceli, Asli; Goksu, Gökçe; Ocal, Zehra

doi:10.2174/1570179411310030010

Synthesis of New Aryl(Hetaryl)-Substituted Tandospirones Under Reductive Heck Type Hydroarylations and Isoxazoline Derivatives via 1,3-Dipolar Cycloaddition Reactions with Expected Anxiolytic Activity

Kulu I., Kopruceli A., Goksu G., Ocal N.

CURRENT ORGANIC SYNTHESIS, cilt.10, sa.3, ss.481-485, 2013 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 10 Sayı: 3
Basım Tarihi: 2013
Doi Numarası: 10.2174/1570179411310030010
Dergi Adı: CURRENT ORGANIC SYNTHESIS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.481-485
Yıldız Teknik Üniversitesi Adresli: Evet

Özet

The C-C coupling of bicyclic alkene 4 with aryl and heteroaryl iodides gave under reductive Heck conditions the Caryl(hetaryl), N-[((4-pyrimidin-2-yl) piperazin-1-yl) butyl] substituted bicyclic imides 5a-f. The [3+2] cycloadditions of 4 with various nitrile oxides yielded the bridged isoxazoline derivatives 6-8 with potential biological activity.