Synthesis of New Aryl(Hetaryl)-Substituted Tandospirones Under Reductive Heck Type Hydroarylations and Isoxazoline Derivatives via 1,3-Dipolar Cycloaddition Reactions with Expected Anxiolytic Activity

Kulu I., Kopruceli A., Goksu G., Ocal N.

CURRENT ORGANIC SYNTHESIS, cilt.10, sa.3, ss.481-485, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.2174/1570179411310030010
  • Dergi Adı: CURRENT ORGANIC SYNTHESIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.481-485
  • Yıldız Teknik Üniversitesi Adresli: Evet

Özet

The C-C coupling of bicyclic alkene 4 with aryl and heteroaryl iodides gave under reductive Heck conditions the Caryl(hetaryl), N-[((4-pyrimidin-2-yl) piperazin-1-yl) butyl] substituted bicyclic imides 5a-f. The [3+2] cycloadditions of 4 with various nitrile oxides yielded the bridged isoxazoline derivatives 6-8 with potential biological activity.