Synthesis of New Aryl(Hetaryl)-Substituted Tandospirones Under Reductive Heck Type Hydroarylations and Isoxazoline Derivatives via 1,3-Dipolar Cycloaddition Reactions with Expected Anxiolytic Activity


Kulu I., Kopruceli A., Goksu G. , Ocal N.

CURRENT ORGANIC SYNTHESIS, vol.10, no.3, pp.481-485, 2013 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.2174/1570179411310030010
  • Title of Journal : CURRENT ORGANIC SYNTHESIS
  • Page Numbers: pp.481-485

Abstract

The C-C coupling of bicyclic alkene 4 with aryl and heteroaryl iodides gave under reductive Heck conditions the Caryl(hetaryl), N-[((4-pyrimidin-2-yl) piperazin-1-yl) butyl] substituted bicyclic imides 5a-f. The [3+2] cycloadditions of 4 with various nitrile oxides yielded the bridged isoxazoline derivatives 6-8 with potential biological activity.