Electrochemical Determination of Paracetamol by a Novel Derivative of Formazan Modified Pencil Graphite Electrode

Görçay H., Türkoğlu G., ŞAHİN Y., Berber H.

IEEE SENSORS JOURNAL, cilt.14, sa.8, ss.2529-2536, 2014 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 8
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1109/jsen.2014.2311296
  • Dergi Adı: IEEE SENSORS JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2529-2536
  • Anahtar Kelimeler: Differential pulse voltammetry, formazan derivative, modified electrode, paracetamol, pencil graphite, voltammetry, GLASSY-CARBON ELECTRODE, SIMULTANEOUS VOLTAMMETRIC DETERMINATION, UV SPECTROPHOTOMETRIC METHOD, CATECHOLAMINE NEUROTRANSMITTERS, AMPEROMETRIC DETERMINATION, ASCORBIC-ACID, ACETAMINOPHEN, SENSOR, CAFFEINE, ELECTROPHORESIS
  • Yıldız Teknik Üniversitesi Adresli: Evet

Özet

A modified electrode, based on electrodeposition of 5,5'-(oxybis(4,1-phenylene))bis(3-(2-hydroxyphenyl)-1-phenylformazan (BF) onto pencil graphite (PG) electrode, was investigated for the determination of paracetamol in this paper. BF was synthesized for the first time in this paper and used for the modification of PG electrode. The electrochemical performance of the modified (BF/PG) electrodes was investigated by differential pulse voltammetry at phosphate buffer solution. Several important parameters controlling the performance of the BF/PG was investigated and optimized. Two linear regions were observed. The first region demonstrates linearity over a concentration range of 0.05-1 mu M with a correlation coefficient (R-2) of 0.996. The slope of the second linear region was smaller than the first region's slope with a wide concentration range of 1-100 mu M (R-2 = 0.976). The detection limit of paracetamol is 2.4x10(-9) M (S/N = 3). The proposed low cost BF/PG electrode, showed a stable and reproducible response without any influence of interferents commonly existing in pharmaceutical samples.