Climate control in museums is carried out with the aim of preventing or delaying the deterioration of collections and reducing the need for remedial conservation interventions that are directly applied to objects, which can also involve various risks. In this context, extreme levels of temperature and relative humidity and short-term fluctuation tendencies are tried to be moderated in the interiors of museums. The process of deciding on the climate control method to be preferred requires considering many important issues. These issues are to reduce the risk of damage to the collections due to environmental variables, to ensure human comfort of museum employees and visitors, to prevent damage and deterioration that may occur in the museum building due to indoor climatic conditions, to carry out accurate and systematic measurements and monitoring for appropriate climate control, to use energy efficiently and to pay attention to the environmental sensitivities. In addition, references that deal with the experiences of the past in a utilitarian way and protection criteria that predict the route and duration of deterioration in museum objects are also important process components that should be considered. Within the scope of the study, it is suggested that the decision-making process on climate control for museums should be carried out with a group activity involving professionals working in related fields. Thus, it is evaluated that climate control problems that may be encountered later can be eliminated or their damage potentials can be reduced by detecting them at an early stage. It is concluded that there is no climate control recipe that can be applied without examining for each museum, but many efficient solutions that can be preferred will provide the targeted performance.