Akademik Veri Yönetim Sistemi
6th International Eurasian Conference on Biological and Chemical Sciences, Ankara, Türkiye, 11 - 13 Ekim 2023, ss.1488
Multiple sclerosis (MS) is the leading cause of neurological disability among adults and affects women three
times more than men. Among the subtypes of MS, Remitting-Relapsing MS (RRMS) is the most common,
characterized by disease states of remission and relapse, often transitioning to Secondary Progressive MS
(SPMS). While the RRMS phase is marked by inflammatory processes, the SPMS phase is marked by
neurodegeneration. Scientific evidence indicates that circulating microRNAs (miRNAs) play a significant role
in various cellular and physiological functions. miRNAs circulate stably in human blood and are sensitive to
processes occurring in the organism. miRNAs have been demonstrated to exert significant effects on MS
pathology, with extensive investigations having been conducted and continuing inquiries pursued in this realm.
Comprehensive studies on miRNAs exhibiting differing expression levels in male and female patients during
the RRMS phase are lacking in the literature. In our study, we employed bioinformatics tools such as GEO2R,
Cytoscape, and Morpheus to investigate the differences between remission and relapse disease states of RRMS
in male and female subjects. MiRNAs displaying deviant expressions were analysed for both disease states
and genders. The results of our investigation reveal that miRNAs with distinct expression levels during the
remission and relapse phases of RRMS exhibit gender-specific variations. According to the results that will be
obtained from this study, it is believed that specific miRNAs capable of distinguishing MS subtypes can be
identified. Furthermore, gender-specific potential biomarkers can be discovered by assessing the shared and
non-shared miRNAs between females and males. Additionally, there is potential for the identification of
miRNAs that could be implicated in prospective treatment and drug development endeavours.