Research Information System
EACR 2025 Congress: Innovative Cancer Science, Lisbon, Portugal, 16 - 19 June 2025, vol.19, no.15747891, pp.266-267, (Summary Text)
Mitochondria regulate cellular homeostasis, energyproduction, and apoptosis through fusion, fission, andmitophagy. Disruptions in these processes are linked tocancer and neurodegenerative diseases, with mitophagyplaying a key role in stress responses.Naringenin, a citrusflavonoid, exhibits antioxidant, anti-inflammatory, andanticancer effects. While it influences mitochondrialdynamics, its impact on mitophagy remains unclear.This study examines its role in mitophagy and apoptosis,particularly in the PINK1-Parkin pathway andmitochondrial fission.