SYNTHESIS OF NEW TANDOSPIRONE ANALOGUES CARRYING 1-(3-(TRIFLUOROMETHYL)PHENYL)PIPERAZINE


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GÜNKARA Ö. T. , Sucu B. O. , Guleli M., Ocal N.

SYNTHETIC COMMUNICATIONS, vol.44, no.11, pp.1619-1628, 2014 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 11
  • Publication Date: 2014
  • Doi Number: 10.1080/00397911.2013.865236
  • Title of Journal : SYNTHETIC COMMUNICATIONS
  • Page Numbers: pp.1619-1628

Abstract

New tandospirone analogues containing a 1-[3-(trifluoromethyl) phenyl] piperazine (TFMPP) moiety have been synthesized by hydroarylation reactions with Pd(OAc)(2). The perhydroisoindole derivatives were obtained by the reaction of reduced starting material with aryl-(heteroaryl) iodides under the same conditions. Spiro-1,3-indandionolylpyrrolidine derivatives having an array of stereocenters are reported.