SYNTHESIS OF NEW TANDOSPIRONE ANALOGUES CARRYING 1-(3-(TRIFLUOROMETHYL)PHENYL)PIPERAZINE


GÜNKARA Ö. T. , Sucu B. O. , Guleli M., Ocal N.

SYNTHETIC COMMUNICATIONS, cilt.44, ss.1619-1628, 2014 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 44 Konu: 11
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1080/00397911.2013.865236
  • Dergi Adı: SYNTHETIC COMMUNICATIONS
  • Sayfa Sayıları: ss.1619-1628

Özet

New tandospirone analogues containing a 1-[3-(trifluoromethyl) phenyl] piperazine (TFMPP) moiety have been synthesized by hydroarylation reactions with Pd(OAc)(2). The perhydroisoindole derivatives were obtained by the reaction of reduced starting material with aryl-(heteroaryl) iodides under the same conditions. Spiro-1,3-indandionolylpyrrolidine derivatives having an array of stereocenters are reported.