10.Ulusal Moleküler Biyoloji ve Biyoteknoloji Kongresi, Mersin, Turkey, 17 - 19 December 2021, vol.1, no.1, pp.1
Adsorption of Hydroxychloroquine Used in the Treatment of COVID-19 on Graphene Surface
COVID-19 is a virus that was first identified on January 13, 2020, as a result of research conducted in a group of patients who developed respiratory symptoms (fever, cough, shortness of breath) in Wuhan, China, in December 2019. Since then, many vaccine and drug studies have been carried out. Some of these researches have yielded results, and vaccines and drugs are approved by the World Health Organization for emergency use. Hydroxychloroquine (HCQ), an analogue of Chloroquine (CQ), a malaria drug, is one of the drugs used for the treatment and prevention of COVID-19. However, in addition to the possible side effects and harmful interactions of HCQ, many clinical studies have shown that the drug has caused serious problems in patients such as heart complications, headache, dizziness, nausea, stomach pain, irritability. To eliminate these side effects of HCQ, HCQ has been combined with various platforms such as Ag, Au, and Pt nanoparticles to date. Graphene is an allotrope of carbon consisting of a single layer of atoms arranged in a two-dimensional honeycomb lattice nanostructure. Graphene is the most outstanding material among the new nanostructured carbonaceous species discovered and produced. The properties of graphene such as electronic conductivity, mechanical strength, and large surface area have provided a profound change in the field of materials science.
In this study, it is aimed to adsorb HCQ to the surface of S-doped graphene powders and to characterize this new carrier system for HCQ. First of all, S-doped graphene powders were synthesized in different potential ranges by using cyclic voltammetry via Yucel's method and various characterizations were performed. Then, the adsorption of HCQ at different concentrations on the surface of S-doped graphene powders was studied. For quantitative determinations, a calibration curve was created using UV-Vis of HCQ. In addition, the effects of pH and different buffer solutions on adsorption efficiency were investigated. It is predicted that this system created for HCQ can reduce the side effects of HCQ, and cytotoxicity studies are continuing as further research to determine this.
Keywords: COVID-19, Hydroxychloroquine, S-doped graphene powders, Adsorption