Akademik Veri Yönetim Sistemi
10.Ulusal Moleküler Biyoloji ve Biyoteknoloji Kongresi, Mersin, Türkiye, 17 - 19 Aralık 2021, cilt.1, sa.1, ss.1
Adsorption of Hydroxychloroquine Used
in the Treatment of COVID-19 on Graphene Surface
Abstract
COVID-19 is a virus that was first identified on
January 13, 2020, as a result of research conducted in a group of patients who
developed respiratory symptoms (fever, cough, shortness of breath) in Wuhan,
China, in December 2019. Since then, many vaccine and drug studies have been
carried out. Some of these researches have yielded results, and vaccines and
drugs are approved by the World Health Organization for emergency use.
Hydroxychloroquine (HCQ), an analogue of Chloroquine (CQ), a malaria drug, is
one of the drugs used for the treatment and prevention of COVID-19. However, in
addition to the possible side effects and harmful interactions of HCQ, many
clinical studies have shown that the drug has caused serious problems in
patients such as heart complications, headache, dizziness, nausea, stomach
pain, irritability. To eliminate these side effects of HCQ, HCQ has been
combined with various platforms such as Ag, Au, and Pt nanoparticles to date.
Graphene is an allotrope of carbon consisting of a single layer of atoms
arranged in a two-dimensional honeycomb lattice nanostructure. Graphene is the
most outstanding material among the new nanostructured carbonaceous species
discovered and produced. The properties of graphene such as electronic
conductivity, mechanical strength, and large surface area have provided a
profound change in the field of materials science.
In this study, it is aimed to adsorb HCQ to the
surface of S-doped graphene powders and to characterize this new carrier system
for HCQ. First of all, S-doped graphene powders were synthesized in different
potential ranges by using cyclic voltammetry via Yucel's method and various
characterizations were performed. Then, the adsorption of HCQ at different
concentrations on the surface of S-doped graphene powders was studied. For
quantitative determinations, a calibration curve was created using UV-Vis of
HCQ. In addition, the effects of pH and different buffer solutions on
adsorption efficiency were investigated. It is predicted that this system
created for HCQ can reduce the side effects of HCQ, and cytotoxicity studies
are continuing as further research to determine this.
Keywords: COVID-19,
Hydroxychloroquine, S-doped graphene powders, Adsorption