A Spectrophotometric Method for the Determination of Prazosin Hydrochloride in Tablets

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Özgür M. , Sungur S.

Turkish Journal Of Chemistry, no.26, pp.691-696, 2002 (Journal Indexed in SCI Expanded)

  • Publication Type: Article / Article
  • Publication Date: 2002
  • Title of Journal : Turkish Journal Of Chemistry
  • Page Numbers: pp.691-696


A rapid and sensitive analytical method was developed for the spectrophotometric assay of prazosin

hydrochloride. The method is based on the formation of a coloured derivative between the drug and

1,2-naphthoquinone-4- sulphonic acid sodium salt (NQS). The reaction proceeds quantitatively at pH

4.5 and 70  C for 40 min. After the extraction of the derivative with chloroform: n-butanol (3:1), the

absorbance was measured at 400 nm. The method was applied to commercially available tablets and the

results were statistically compared with those obtained by ultraviolet spectrophotometric and di erential

pulse polarographic methods using t- and F-tests.