Turkish Journal Of Chemistry, no.26, pp.691-696, 2002 (Journal Indexed in SCI Expanded)
A rapid and sensitive analytical method was developed for the spectrophotometric assay of prazosin
hydrochloride. The method is based on the formation of a coloured derivative between the drug and
1,2-naphthoquinone-4- sulphonic acid sodium salt (NQS). The reaction proceeds quantitatively at pH
4.5 and 70 C for 40 min. After the extraction of the derivative with chloroform: n-butanol (3:1), the
absorbance was measured at 400 nm. The method was applied to commercially available tablets and the
results were statistically compared with those obtained by ultraviolet spectrophotometric and dierential
pulse polarographic methods using t- and F-tests.