Reductive metallation of 6-methyl-2,3-diphenylquinoxaline. Synthesis of 1,4-dihydro-1,4-diazine derivatives

Ocal N., Turgut Z., Kaban S.

JOURNAL OF HETEROCYCLIC CHEMISTRY, cilt.35, sa.6, ss.1349-1351, 1998 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 6
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1002/jhet.5570350620
  • Dergi Adı: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1349-1351
  • Yıldız Teknik Üniversitesi Adresli: Evet

Özet

The reductive metallation of 6-methyl-2,3-diphenylquinoxaline 1 with sodium metal in tetrahydrofuran and inert atmosphere to a monomeric dianion 2 has been explored and the nucleophilicity of this disodium adduct was investigated with various alkylation and acylation reagents. An annulation of the pyrazine ring system was accomplished by treating the dianion with polymethylene chlorides, CI(CH2)(n)Cl, n = 3.4.