Synthesis and Characterization of Novel Non-Peripheral Phthalocyanines for Efficient Singlet Oxygen Generation: Comparison of Photochemical and Sonophotochemical Methods
Journal of Fluorescence, vol.36, no.7, pp.4417-4428, 2026 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 36 Issue: 7
- Publication Date: 2026
- Doi Number: 10.1007/s10895-026-04835-z
- Journal Name: Journal of Fluorescence
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chimica, Compendex, EMBASE, MEDLINE, Academic Search Ultimate (EBSCO), Natural Science Collection (ProQuest), Biological Science Database (ProQuest), Engineering Source (EBSCO), Materials Science & Engineering Collection (ProQuest), Technology Collection (ProQuest)
- Page Numbers: pp.4417-4428
- Keywords: Combination therapy, Photodynamic therapy, Phthalocyanine, Singlet oxygen generation
- Yıldız Technical University Affiliated: Yes
Abstract
Recent advancements in sonophotodynamic therapy (SPDT) have highlighted the growing demand for the development of novel and effective sonosensitizers/sonophotosensitizers for cancer treatment. Among the various candidates, phthalocyanines have attracted significant attention due to their highly versatile molecular structures and tunable photophysical and physicochemical properties. In this study, 3-[4-(hexyl benzoate)] substituted metallophthalocyanines were synthesized with peripheral substitution and comprehensively characterized using standard spectroscopic techniques. The singlet oxygen generation efficiencies of the synthesized compounds were systematically evaluated under photochemical and sonophotochemical conditions. The results demonstrate that the newly designed phthalocyanines possess promising potential as efficient sensitizers for both PDT and SPDT applications, offering synergistic enhancement in singlet oxygen production.