Subclinical Lung Disease, Macrocytosis, and Premature Graying in Kindreds With Telomerase (TERT) Mutations

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DE LEON A. D., CRONKHITE J. T., Yilmaz C., BREWINGTON C., WANG R., XING C., ...Daha Fazla

CHEST, cilt.140, sa.3, ss.753-763, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 140 Sayı: 3
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1378/chest.10-2865
  • Dergi Adı: CHEST
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.753-763
  • Yıldız Teknik Üniversitesi Adresli: Hayır

Özet

Background: Mutations in the human gene encoding the protein component of telomerase (TERT) are the most common genetic defect in patients with familial idiopathic pulmonary fibrosis (IPF). The subclinical phenotypes of asymptomatic members of these families have not been evaluated with respect to TERT mutation status or telomere length.