Masonry walls are systems that are typically preferred in conventional structures. The complex structure of masonry walls makes it harder to determine wall behavior; however, wall behavior is affected by the types of material used in conventional walls and the way in which joints interact with masonry units. The aim of this study is to investigate the effect of joint thickness and material factors on wall performance. To accomplish this, materials used in historical and conventional structures are preferred. This study involved hollow bricks, clay bricks, NHL 3.5, and CEM 32.5. Three different joint thicknesses were used to set up 12 different combinations. Damage estimation of the wall was carried out by moving a live load under a constant vertical load. Different materials of different joint thicknesses and mechanical properties were studied for their effects on the wall. The results indicated that a joint thickness of 20 mm preferred in wall production was more convenient. The strength of walls produced from durable material was found to be higher.