Kinetic Analysis of the Amino Terminal End of Active Site Loop of Lactate Deyhdrogenase from Plasmodium Vivax

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MUTLU Ö., Turgut-Balik D.

BALKAN MEDICAL JOURNAL, cilt.29, sa.4, ss.364-369, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.5152/balkanmedj.2012.047
  • Dergi Adı: BALKAN MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.364-369
  • Anahtar Kelimeler: Lactate dehydrogenase, Plasmodium vivax, antimalarial drug, site-directed mutagenesis, kinetic analysis, DEHYDROGENASE GENE, FALCIPARUM, EXPRESSION, PARASITE, MALARIA, CLONING
  • Yıldız Teknik Üniversitesi Adresli: Evet

Özet

Objective: In this study, kinetic analysis was performed to understand the functional importance of the amino terminal of the active site of previously mutated Plasmodium vivax Lactate Dehydrogenase enzyme by mimicking Toxoplasma gondii I, II, Eimeria acervulina and Eimeria tenella LDH's.