Curcumin Effect on HAS2 Gene Expression on Senescent Fibroblasts

Neziri S., Özdemir Özgentürk N., Kandemiş E.

5 International Student Science Congress, İzmir, Turkey, 21 May - 22 December 2021, pp.23

  • Publication Type: Conference Paper / Summary Text
  • City: İzmir
  • Country: Turkey
  • Page Numbers: pp.23
  • Yıldız Technical University Affiliated: Yes


People's lifestyle, the environment they live in and the products they use cause changes in their gene expression. Changes in living conditions have a direct impact on the body. One of the most affected processes is the aging process. In our research we examined the effect of curcumin in the aging process of human skin fibroblasts. Aging is directly related to many changes in the cell. DNA is exposed to changes such as shortening of telomeres, chromatin changes, DNA methylation, and some of these changes can be used as biomarkers. Two groups were used; the control group not treated with any agent and the experimental group exposed to the anti-aging agent (curcumin). Both groups were exposed to the normal aging process. Total RNA was isolated from the cells incubated under appropriate conditions and then the expression level of the target genes were analyzed using real-time polymerase chain reaction. Our aim is to analyze the anti-aging effect of curcumin, which is widely used in cosmetics.