Akademik Veri Yönetim Sistemi
11. İlaç Kimyası Kongresi, Antalya, Türkiye, 9 - 12 Mart 2023, ss.188
In recent years, the concept of hybrid molecules containing two or more pharmacophore groups
covalently linked together in a single molecular framework has been introduced. Hybrid molecules are
of great interest in the field of medicinal chemistry and drug discovery. It has been suggested that such
compounds are capable of simultaneously inhibiting two or more conventional targets. This multitarget strategy has led to the development of a series of bioactive hybrid molecules (Yılmaz, 2017).
Many synthetic coumarins containing one type of pharmacophoric group at positions C-3, C-4 and C-7
have been extensively screened for different biological properties. In recent years, coumarins have
been tested as anti-HIV, anticancer, anti-microbial, antioxidant, anti-Alzheimer's, anti-tuberculosis,
anti-platelet activity, COX inhibitors, anti-inflammatory, anti-asthmatic, anti-viral and DNA gyrase
inhibitors. lots of research has been done. Coumarin and its derivatives; They are of great interest in
the design of various drugs, both because of their potential applications in drug research and because
of their broad spectrum of biological activity. The addition of various heterocycles to the coumarin
motif affects both the pharmacological and biochemical properties of coumarin, including its
therapeutic applications (Carneiro, 2021). Coumarin-azole hybrids are promising biological agents that
increase pharmacological activity. Coumarins containing triazole moieties are of great interest to
researchers and are widely used as anticancer scaffolds (Rawat, 2022).
In this study, based on the coumarin motif, the synthesis of new triazole-coumarin hybrid compounds
with the potential to exhibit various biological activities was carried out using 'Click' chemistry.
Keywords: Coumarin derivatives, azole, click chemistry, hybrid molecule
Acknowledgement: This work supported by YTU Scientific Research Foundation [Project Number FYL2002-4811].
References
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2. Carneiro, A., Matos, M.J., Uriarte, E., Santana, L., Molecules 2021, 26, 501.
3. Rawat, A., Reddy, A. V. B., Eur. J.Med. Chem. Reports 2022, 5, 100038.