Synthesis and Applications of Novel Coumarin-Triazole Hybrid Compounds

Arvas B., Aydoğan F., Yolaçan Ç.

11. İlaç Kimyası Kongresi, Antalya, Turkey, 9 - 12 March 2023, pp.188

  • Publication Type: Conference Paper / Summary Text
  • City: Antalya
  • Country: Turkey
  • Page Numbers: pp.188
  • Yıldız Technical University Affiliated: Yes


In recent years, the concept of hybrid molecules containing two or more pharmacophore groups covalently linked together in a single molecular framework has been introduced. Hybrid molecules are of great interest in the field of medicinal chemistry and drug discovery. It has been suggested that such compounds are capable of simultaneously inhibiting two or more conventional targets. This multitarget strategy has led to the development of a series of bioactive hybrid molecules (Yılmaz, 2017). Many synthetic coumarins containing one type of pharmacophoric group at positions C-3, C-4 and C-7 have been extensively screened for different biological properties. In recent years, coumarins have been tested as anti-HIV, anticancer, anti-microbial, antioxidant, anti-Alzheimer's, anti-tuberculosis, anti-platelet activity, COX inhibitors, anti-inflammatory, anti-asthmatic, anti-viral and DNA gyrase inhibitors. lots of research has been done. Coumarin and its derivatives; They are of great interest in the design of various drugs, both because of their potential applications in drug research and because of their broad spectrum of biological activity. The addition of various heterocycles to the coumarin motif affects both the pharmacological and biochemical properties of coumarin, including its therapeutic applications (Carneiro, 2021). Coumarin-azole hybrids are promising biological agents that increase pharmacological activity. Coumarins containing triazole moieties are of great interest to researchers and are widely used as anticancer scaffolds (Rawat, 2022). In this study, based on the coumarin motif, the synthesis of new triazole-coumarin hybrid compounds with the potential to exhibit various biological activities was carried out using 'Click' chemistry. Keywords: Coumarin derivatives, azole, click chemistry, hybrid molecule Acknowledgement: This work supported by YTU Scientific Research Foundation [Project Number FYL2002-4811]. References 1. Yilmaz, F., Hinge, M., Rev. rum chim. 2017, 62 (12), 941. 2. Carneiro, A., Matos, M.J., Uriarte, E., Santana, L., Molecules 2021, 26, 501. 3. Rawat, A., Reddy, A. V. B., Eur. J.Med. Chem. Reports 2022, 5, 100038.