Automatic analysis of the control of metabolic networks


Bayram M.

COMPUTERS IN BIOLOGY AND MEDICINE, vol.26, no.5, pp.401-408, 1996 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 5
  • Publication Date: 1996
  • Doi Number: 10.1016/0010-4825(96)00011-x
  • Title of Journal : COMPUTERS IN BIOLOGY AND MEDICINE
  • Page Numbers: pp.401-408

Abstract

In this paper we apply computer algebra techniques to analyze the control of metabolic networks. For this purpose, a computer program based on metabolic control theory was developed. When a stoichiometry matrix of the metabolic networks is given, the program calculates all the control coefficients (flux and metabolic control coefficients, summation and connectivity relationships) using elasticity coefficients. The program can be applied to any metabolic network which includes unlimited steps and intermediate metabolites.