Akademik Veri Yönetim Sistemi
BALKAN 10th INTERNATIONAL CONFERENCE ON APPLIED SCIENCES, Kırklareli, Türkiye, 6 - 08 Ocak 2024, ss.49
Acridinediones and their derivatives possess a wide range of pharmaceutical activities,
including antimicrobial, antimalarial, antitumor, anticancer, antibacterial, fungicidal, and DNA
binding properties. These derivatives have beenused in chemotherapy for the treatment of
cancer and in the treatment of cardiovascular diseases, such as angina pectorisand hypertension.
In addition, acridinediones exhibit important properties such as high fluorescence efficiency
allowing them to be used as laser dyes1.
In our studies the reaction between dimedone (2 mmol), substitutedbenzaldehyde (1 mmol),
and aryl amine (or ammonium acetate) (1 mmol) was performed in traditional organic solvent,
EtOH. The reaction mixture was stirred for 8h at 80oC to obtain of N-substituted
decahydroacridine-1,8-dione. Firstly, a three-component one-pot system was performed in the
presence of a catalyst, Praseodymium(III) trifluoromethanesulfonate, Pr(OTf)3.
Then, 3,3,6,6-Tetramethyl-9,10-(substituted phenyl)-3,4,6,7,9,10-hexahydroacridine -1,8
(2H,5H)-dione acridine-dione compounds were synthesized with good yields by using the stepby-
step reaction method.
Their structures were clarified by IR, NMR (1H and 13C) spectra.