Gene Selection and Classification Approach for Microarray Data based on Random Forest Ranking and BBHA

PASHAEI E., Ozen M., AYDIN N.

3rd IEEE EMBS International Conference on Biomedical and Health Informatics (IEEE BHI), Nevada, Amerika Birleşik Devletleri, 24 - 27 Şubat 2016, ss.308-311 identifier identifier

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Doi Numarası: 10.1109/bhi.2016.7455896
  • Basıldığı Şehir: Nevada
  • Basıldığı Ülke: Amerika Birleşik Devletleri
  • Sayfa Sayıları: ss.308-311
  • Anahtar Kelimeler: Gene selection, random forest ranking, black hole algorithm, bagging
  • Yıldız Teknik Üniversitesi Adresli: Evet

Özet

In this paper, a novel approach based on Binary Black Hole Algorithm (BBHA) and Random Forest Ranking (RFR) is proposed for gene selection and classification of microarray data. In this approach, RFR and BBHA are used to perform gene selection to remove irrelevant and redundant genes. Because of its ability in reducing noise, bias and variance errors Bagging with 10-fold cross validation is selected as a classifier. The result of RFR-BBHA-Bagging is compared to seven benchmark classification methods. Experimental results show that our proposed method by selecting the least number of informative genes can increase prediction accuracy of Bagging and outperforms the other classification methods.