Evaluation of mono- and dipeptides as organocatalysts for enantioselective aldol reaction


Yolaçan Ç. , Mavıs M. E. , Aydoğan F.

TETRAHEDRON, cilt.70, ss.3707-3713, 2014 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 70
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.tet.2014.04.016
  • Dergi Adı: TETRAHEDRON
  • Sayfa Sayıları: ss.3707-3713

Özet

Catalytic activities of (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (THIQA)-based mono- and dipeptides and their L-proline analogs in asymmetric aldol reaction were investigated. THIQA-based dipeptides showed better enantioselectivity than proline analogs, whereas proline-based dipeptides gave higher yield in the aldol reaction of cyclohexanone with several aldehydes in dichloromethane at -10 degrees C in the presence of benzoic acid. (C) 2014 Elsevier Ltd. All rights reserved.