Electrochemically synthesized VOSO₄-doped polypyrrole on pencil grapHite electrode for highly sensitive dopamine detection in biological and pharmaceutical samples
Microchemical Journal, cilt.224, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 224
- Basım Tarihi: 2026
- Doi Numarası: 10.1016/j.microc.2026.117736
- Dergi Adı: Microchemical Journal
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, Chimica, Index Islamicus
- Anahtar Kelimeler: Dopamine, Doped polypyrrole, Electrochemical sensor, Vanadyl sulfate
- Yıldız Teknik Üniversitesi Adresli: Evet
Özet
A highly sensitive and low-cost electrochemical dopamine (DA) sensor was developed via one-step electropolymerization of vanadyl sulfate (VOSO₄)-doped polypyrrole (PPy) onto a pencil graphite electrode (PGE). Under optimized conditions (pH 6.0, 0.1 M phosphate buffer), the electrode exhibited two linear response ranges of 0.05–100 μM (R2 = 0.9996) and 250–1500 μM (R2 = 0.9963). The analytical performance parameters were LOD = 0.03 μM, LOQ = 0.11 μM, and RSD = 3.48%, indicating high sensitivity and good repeatability. The electrode retained 94.0% of its initial current response after 25 days, demonstrating satisfactory storage stability. Real sample analysis provided recovery values of 97.39% (pharmaceutical tablet), 99.96% (human serum), and 97.26% (human urine), confirming the applicability of the sensor in complex matrices. The enhanced electrochemical response is attributed to the conductive PPy matrix and the redox-active V4+/V5+ centers, which facilitate charge transfer and electrocatalytic activity. Overall, the PGE/PPy/VOSO₄ electrode offers a low detection limit, broad linear range, good reproducibility, and low fabrication cost, making it a promising platform for dopamine determination in pharmaceutical and biological samples.