Synthesis of hydroxyapatite crystals using carboxymethyl inulin for use as a delivery of ibuprofen


ÖNER M. , UYSAL U.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, vol.33, no.1, pp.482-489, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.1016/j.msec.2012.09.018
  • Title of Journal : MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
  • Page Numbers: pp.482-489

Abstract

In the present study biodegradable, environmentally friendly polysaccharide-based polycarboxylate, carboxymethyl inulin (CMI), was used to produce hydroxyapatite (HAP) particles by wet chemical synthesis under controlled temperature, pH, and atmospheric conditions. The morphology and microstructure of the HAP nanoparticles were investigated by XRD, SEM, DTA-TGA and FTIR. CMI affects morphology, surface area, dimension and particle size distribution of the crystals. The reduction in size is greater in the direction of the c-axis. The increase in the polymer concentration to 7.5 g/L resulted in the mixture of nanoparticles with particle sizes of less than 100 nm. The SEM micrograph shows the formation of well-crystallized, agglomerated small particles of HAP. X-ray analysis has Shown that the resulting particles have high thermal stability.