Simple Determination of Cystine in Artificial Urine and Drug Matrices Using Digital Image Colorimetry
ANALYTICAL LETTERS, sa.58, ss.1-15, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2025
- Doi Numarası: 10.1080/00032719.2025.2517118
- Dergi Adı: ANALYTICAL LETTERS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Food Science & Technology Abstracts, Metadex, Veterinary Science Database, Civil Engineering Abstracts
- Sayfa Sayıları: ss.1-15
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Yıldız Teknik Üniversitesi Adresli: Evet
Özet
Smartphone-based digital image colorimetry was developed for thedetermination of cystine in pharmaceutical formulations and artificialurine samples. A lab-made colorimetric box was designed for captur-ing the digital images of sample solutions using a smartphone. Thedeveloped method employs a simple colorimetric method callednitroprusside test which specifically targets free -SH groups. Cystinewas reduced to cysteine before the colorimetric test was applied.The color intensity is inversely related to the concentration of theanalyte. The best linearity was obtained with the G color channel.Digital image processing was performed using the RGB ColorDetector mobile application to obtain analytical data. The developedmethod exhibited good linearity in the range of 29.7–00.3 mg/kg.The limits of detection and quantification were 9.7 mg/kg and32.3 mg/kg, respectively. The percent recoveries were 104.2 ± 7.8%and 108.7 ± 4.6%, which proved the accuracy and applicability of thedeveloped method