Synthesis and characterization of new phthalocyanines providing effective singlet oxygen production and comparison of photochemically and sonophotochemically methods

Aksoy F., Kılıçarslan F., CAN KARANLIK C., ERDOĞMUŞ A.

POLYHEDRON, vol.282, 2025 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 282
  • Publication Date: 2025
  • Doi Number: 10.1016/j.poly.2025.117792
  • Journal Name: POLYHEDRON
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica, Compendex
  • Keywords: Combination therapy, Photodynamic therapy, Phthalocyanine, Singlet oxygen generation
  • Yıldız Technical University Affiliated: Yes

Abstract

The recently significant results in effective medical treatment in Sonophotodynamic Therapy (SPDT) applications have highlighted the importance of the design of new sonosensitizers/sonophotosensitizers. Thanks to their versalite molecular structure and tunable photophsicochemical features, phthalocyanines have gained remarkalbe attention. Encouraged by these results bis 4-[(6-bromonaphthalene-2)-ol] substituted metallophthalocyanines at peripheral positions were synthesized and characterized. The singlet oxygen production capacities of the newly synthesized compounds were investigated in sonochemically, photochemically and sonophotochemically. In all experiments, InPc-4 have highest singlet oxygen production capacity. Zn-Pc and MgPc singlet oxygen quantum yield were 0.38 and 0.28 in photochemical methods. Obtained result showed that, InPc is a promising sensitizer for all application. On the other hand MgPc and ZnPc are suitable for sonophotochemically applications.