Synthesis and characterization of new phthalocyanines providing effective singlet oxygen production and comparison of photochemically and sonophotochemically methods
POLYHEDRON, cilt.282, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 282
- Basım Tarihi: 2025
- Doi Numarası: 10.1016/j.poly.2025.117792
- Dergi Adı: POLYHEDRON
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica, Compendex
- Anahtar Kelimeler: Combination therapy, Photodynamic therapy, Phthalocyanine, Singlet oxygen generation
- Yıldız Teknik Üniversitesi Adresli: Evet
Özet
The recently significant results in effective medical treatment in Sonophotodynamic Therapy (SPDT) applications have highlighted the importance of the design of new sonosensitizers/sonophotosensitizers. Thanks to their versalite molecular structure and tunable photophsicochemical features, phthalocyanines have gained remarkalbe attention. Encouraged by these results bis 4-[(6-bromonaphthalene-2)-ol] substituted metallophthalocyanines at peripheral positions were synthesized and characterized. The singlet oxygen production capacities of the newly synthesized compounds were investigated in sonochemically, photochemically and sonophotochemically. In all experiments, InPc-4 have highest singlet oxygen production capacity. Zn-Pc and MgPc singlet oxygen quantum yield were 0.38 and 0.28 in photochemical methods. Obtained result showed that, InPc is a promising sensitizer for all application. On the other hand MgPc and ZnPc are suitable for sonophotochemically applications.