Electrosprayed Collagen/Gentamicin nanoparticles coated microneedle patches for skin treatment


Mutlu M. E. , Ulag S., ŞENGÖR M., DAĞLILAR S., Narayan R., GÜNDÜZ O.

MATERIALS LETTERS, vol.305, 2021 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 305
  • Publication Date: 2021
  • Doi Number: 10.1016/j.matlet.2021.130844
  • Journal Name: MATERIALS LETTERS
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, Aerospace Database, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Keywords: Collagen type I, Electrospraying, Gentamicin, Microneedle, Nanoparticles, 3D printing, RELEASE

Abstract

In this study, biocompatible microneedle patches were fabricated with three dimensional stereolithography (3D SLA) printer and coated with Gentamicin (GEN)-loaded Collagen (COL) nanoparticles fabricated with the electrospray method. The SEM results of the microneedles and COL/GEN nanoparticles coated microneedles showed that the nanosized microneedles were fabricated successfully, and these microneedles were coated with 1% COL/ GEN solutions homogeneously. The release profiles of the GEN from the 1% COL/GEN nanoparticles coated microneedles reported that the drug was completely released within 540 min.