Electrosprayed Collagen/Gentamicin nanoparticles coated microneedle patches for skin treatment

Mutlu M. E., Ulag S., ŞENGÖR M., DAĞLILAR S., Narayan R., GÜNDÜZ O.

MATERIALS LETTERS, vol.305, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 305
  • Publication Date: 2021
  • Doi Number: 10.1016/j.matlet.2021.130844
  • Journal Name: MATERIALS LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Keywords: Collagen type I, Electrospraying, Gentamicin, Microneedle, Nanoparticles, 3D printing, RELEASE
  • Yıldız Technical University Affiliated: Yes

Abstract

In this study, biocompatible microneedle patches were fabricated with three dimensional stereolithography (3D SLA) printer and coated with Gentamicin (GEN)-loaded Collagen (COL) nanoparticles fabricated with the electrospray method. The SEM results of the microneedles and COL/GEN nanoparticles coated microneedles showed that the nanosized microneedles were fabricated successfully, and these microneedles were coated with 1% COL/ GEN solutions homogeneously. The release profiles of the GEN from the 1% COL/GEN nanoparticles coated microneedles reported that the drug was completely released within 540 min.