New water-soluble cationic indium (III) phthalocyanine bearing thioquinoline moiety; Synthesis, photophysical and photochemical studies with high singlet oxygen yield


Kutlu O. D. , Avcil D., ERDOĞMUŞ A.

MAIN GROUP CHEMISTRY, cilt.18, ss.139-151, 2019 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 18 Konu: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.3233/mgc-180720
  • Dergi Adı: MAIN GROUP CHEMISTRY
  • Sayfa Sayısı: ss.139-151

Özet

The synthesis and characterization of (4) -tetra[2-thioquinoline] phthalocyaninato indium (III) (2) and quaternized (4)-tetra[2-thioquinoline] phthalocyaninato indium (III) (3), are described. Photochemical and photophysical properties of 2 and 3 in DMSO; and of 3 in water are also presented. A comparison between the photophysical and photochemical parameters of 2 and 3 showed that 2 is a better photosensitizer than 3. The quantum yield values of fluorescence (Phi(F)), and singlet oxygen formation (Phi(Delta)) for 2 are 0.012 and 0.74, respectively. These values are higher than those for 3, which exhibited the values 0.006 and 0.66, respectively. The values for 3 in aqueous solution are 0.002 and 0.17 (0.42 plus Triton X-100) respectively due to aggregation behavior in the solution, and these values suggest that indium phthalocyanine 2 and its water-soluble derivative 3 can find use as photosensitizer in the photodynamic therapy (PDT) of cancer.