In this paper, a novel approach to near field regional focusing for non-destructive hyperthermia is presented. It is aimed to use near-field patterns of antenna arrays for non-destructive treatment by heating of cancerous tissues of the body without damaging normal tissues. Initially, near-field radiation pattern of the horn antenna array placed on the body surface is obtained with a fast and reliable method of Analytical Regularization Method (ARM) in vacuum. At the same time, this pattern of the horn antenna array placed on the body surface is simulated in layered lossy environments (i.e., skin, fat, bone, tumor tissue) by Finite Integral Method (FIM). On the next studies, a hybrid method will be constructed between ARM and Method of Moments (MoM) and near-field patterns will be focused on the tumor using of optimization algorithm. In this manner, heat destruction of tumor tissue can be achieved without damaging the healthy parts of the organ. Finally, non-destructive hyperthermia performance of the designed dual-band horn antenna array system result of the theoretical calculations will be tested on artificial organ models.