LETTERS IN DRUG DESIGN & DISCOVERY, vol.14, no.12, pp.1415-1424, 2017 (Journal Indexed in SCI)
Article / Article
LETTERS IN DRUG DESIGN & DISCOVERY
Science Citation Index Expanded (SCI-EXPANDED), Scopus
SAR, bromination, hydroxyquinoline, methoxyquinoline, cyanoquinoline, anticancer effect, cytotoxicity, antitopoisomerase, 8-HYDROXYQUINOLINE, INHIBITORS
Yıldız Technical University Affiliated:
Background: Brominated 8-hydroxy, 8-methoxy, 8-amino quinolines 5, 6, 8, 9 and novel cyano 8-hydroxyquinolines 11, 12 were evaluated in vitro for their anticancer effects on various cell lines. 5,7-Dibromo-5, 7-bromo-6, 7-cyano-11 and 5,7-dicyano-12 8-hydroxyquinolines were shown to have strong antiproliferative activity against various tumor cell lines, including C6 (rat brain tumor), HeLa (human cervix carcinoma), and HT29 (human colon carcinoma) with IC50 values ranged from 6.7 to 25.6 mu g/mL.