Isocoumarins and 3,4-dihydroisocoumarins, amazing natural products: a review


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Saddiqa A., Usman M., Cakmak O.

TURKISH JOURNAL OF CHEMISTRY, vol.41, no.2, pp.153-178, 2017 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Review
  • Volume: 41 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.3906/kim-1604-66
  • Title of Journal : TURKISH JOURNAL OF CHEMISTRY
  • Page Numbers: pp.153-178
  • Keywords: Isocoumarin, synthesis, natural product, biological importance, HYDRANGEAE-DULCIS FOLIUM, O-IODOBENZOIC ACID, MICROBIAL PRODUCTS, ANTIMICROBIAL PRINCIPLES, PHARMACOLOGICAL-ACTIVITY, 1H-2-BENZOPYRAN-1-ONE DERIVATIVES, 3-SUBSTITUTED ISOCOUMARINS, ASYMMETRIC-SYNTHESIS, BIOACTIVE FUNCTIONS, MEDIATED SYNTHESIS

Abstract

The isocoumarins are naturally occurring lactones that constitute an important class of natural products exhibiting an array of biological activities. A wide variety of these lactones have been isolated from natural sources and, due to their remarkable bioactivities and structural diversity, great attention has been focused on their synthesis. This review article focuses on their structural diversity, biological applications, and commonly used synthetic modes.