Multifunctional Protein-Enabled Patterning on Arrayed Ferroelectric Materials

Hnilova M., Liu X., Yuca E., Jia C., Wilson B., Karataş A., ...More

ACS APPLIED MATERIALS & INTERFACES, vol.4, no.4, pp.1865-1871, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 4 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.1021/am300177t
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1865-1871
  • Keywords: heterofunctional proteins, hierarchical assemblies, ferroelectric LiNbO3 substrate, photochemical deposition, protein microarrays, biological-material interface, SELF-ASSEMBLED MONOLAYERS, MOLECULAR BIOMIMETICS, CELL-SURFACE, BINDING, GOLD, PEPTIDE, SPECTROSCOPY, SPECIFICITY, DESIGN, FORM
  • Yıldız Technical University Affiliated: Yes


This study demonstrates a biological route to programming well-defined protein-inorganic interfaces with an arrayed geometry via modular peptide tag technology. To illustrate this concept, we designed a model multifunctional fusion protein, which simultaneously displays a maltose-binding protein (MBP), a green fluorescence protein (GFPuv) and an inorganic-binding peptide (AgBP2C). The fused combinatorially selected AgBP2C tag controls and site-directs the multifunctional fusion protein to immobilize on silver nanoparticle arrays that are fabricated on specific domain surfaces of ferroelectric LiNbO3 via photochemical deposition and in situ synthesis. Our combined peptide-assisted biological and ferroelectric lithography approach offers modular design and versatility in tailoring surface reactivity for fabrication of nanoscale devices in environmentally benign conditions.