Development of biocomposite tissue scaffolds of collagen/gelatin/borondoped bioactive glass prepared through solvent casting/particulate leaching method for bone tissue engineering

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Güney E., Emir C. , Altan D., Yücel S.

Journal Of The Indian Chemical Society, vol.97, no.10, pp.2006-2012, 2020 (Journal Indexed in SCI Expanded)

  • Publication Type: Article / Article
  • Volume: 97 Issue: 10
  • Publication Date: 2020
  • Journal Name: Journal Of The Indian Chemical Society
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Analytical Abstracts, Chemical Abstracts Core, EMBASE
  • Page Numbers: pp.2006-2012
  • Yıldız Technical University Affiliated: Yes


One of the most important issues of modern medicine is the functional and aesthetic reconstruction of bone tissue after any loss. Selection of biomaterials and manufacturing techniques used in the production of tissue scaffolds is very important for bone tissue regeneration capacity. In this study, biocomposite tissue scaffolds were developed using collagen, gelatin, and boron-doped bioactive glass (B-BG). First, to increase bone formation capacity, bioactive glass was modified with Boron and synthesized via sol-gel method. Then, the biocomposite tissue scaffolds were constructed through solvent casting/particulate leaching method by combining the B-BG with collagen/gelatin hybrid polymer solution and right after that the samples were cross-linked by using glutaraldehyde (GA) vapor. The structures of the scaffolds were characterized by scanning electron microscopy (SEM), X-ray diffraction analysis (XRD), and Fourier infrared transformation spectroscopy (FTIR), while hydroxyapatite (HA) accumulation was examined by using simulated body fluid (SBF). Besides, in vitro swelling capacity and degradation of the scaffolds were also investigated. Finally, in vitro cytotoxicity of the tissue scaffolds was evaluated using human osteoblast-like cell line (SaOS-2). All the results of tests revealed that the biocomposite tissue scaffold containing collagen/gelatin/B-BG can be a promising biomaterial to support the healing process of bone defects.