Synthesis and characterization of natural lanthanum labelled DOTA-Peptides for simulating radioactive Ac-225 labeling

Ucar, Burcu

doi:10.1016/j.apradiso.2019.108816

Synthesis and characterization of natural lanthanum labelled DOTA-Peptides for simulating radioactive Ac-225 labeling

Atıf İçin Kopyala

Ucar B.

APPLIED RADIATION AND ISOTOPES, cilt.153, 2019 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 153
Basım Tarihi: 2019
Doi Numarası: 10.1016/j.apradiso.2019.108816
Dergi Adı: APPLIED RADIATION AND ISOTOPES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Yıldız Teknik Üniversitesi Adresli: Evet

Özet

This research aimed to assess the labeling procedure of Lanthanum to DOTATATE and PSMA-617 peptide for simulating Actinium-225 (Ac-225) labeling. For this purpose labeling procedure, purification and characterization conditions were optimized. Results showed that for the high reaction yield labeling, microwave heating should be preferred and Sephadex G10 column was found to be more suitable as a purification system compared to Toyopearl column. For the characterization of complex, more precise and reliable results were obtained by the chromatographic system.