Particle size and zeta potential investigation of synthetic peptide-protein conjugates

DERMAN S., AKDESTE Z. M.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.40, sa.4, ss.282-289, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1515/tjb-2015-0014
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.282-289
  • Anahtar Kelimeler: Particle size, Zeta potential, Synthetic peptide, Conjugation, Foot and mouth disease, Bovine serum albumin, BOVINE SERUM-ALBUMIN, PERFORMANCE LIQUID-CHROMATOGRAPHY, MOUTH-DISEASE, HYDRODYNAMIC SIZE, POLYACRYLIC-ACID, SWISS-MODEL, VACCINE, ANTIBODIES, EPITOPE, NANOPARTICLES
  • Yıldız Teknik Üniversitesi Adresli: Evet

Özet

Objective: Synthetic peptides are not sufficiently large or complex by themselves to induce immune system because of their small size. Synthetic peptides are usually conjugated to different carriers such as proteins and polyelectrolytes to enhance their immunogenic properties and antigen-specific antibody production (Abs) rate. Thus, the aim of this study is synthesis of peptide-protein covalent conjugates, and size and zeta potential analysis of these conjugates.