Particle size and zeta potential investigation of synthetic peptide-protein conjugates

DERMAN S., AKDESTE Z. M.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.40, no.4, pp.282-289, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.1515/tjb-2015-0014
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.282-289
  • Keywords: Particle size, Zeta potential, Synthetic peptide, Conjugation, Foot and mouth disease, Bovine serum albumin, BOVINE SERUM-ALBUMIN, PERFORMANCE LIQUID-CHROMATOGRAPHY, MOUTH-DISEASE, HYDRODYNAMIC SIZE, POLYACRYLIC-ACID, SWISS-MODEL, VACCINE, ANTIBODIES, EPITOPE, NANOPARTICLES
  • Yıldız Technical University Affiliated: Yes

Abstract

Objective: Synthetic peptides are not sufficiently large or complex by themselves to induce immune system because of their small size. Synthetic peptides are usually conjugated to different carriers such as proteins and polyelectrolytes to enhance their immunogenic properties and antigen-specific antibody production (Abs) rate. Thus, the aim of this study is synthesis of peptide-protein covalent conjugates, and size and zeta potential analysis of these conjugates.