Ultrasonic synthesis, characterization of -aminoketones by bismuth(III) triflate and determination of antigenotoxic properties


Ozturkcan S. A. , TURHAN K. , TURGUT Z. , KARADAYI M., GÜLLÜCE M.

TOXICOLOGY AND INDUSTRIAL HEALTH, vol.31, no.10, pp.911-919, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 10
  • Publication Date: 2015
  • Doi Number: 10.1177/0748233713484649
  • Title of Journal : TOXICOLOGY AND INDUSTRIAL HEALTH
  • Page Numbers: pp.911-919
  • Keywords: beta-aminoketones, direct-type Mannich reaction, ultrasonic synthesis, bismuth(III) triflate, antigenotoxic properties, MANNICH-TYPE REACTION, NITRO-N-NITROSOGUANIDINE, EASTERN ANATOLIA REGION, REVERSE MUTATION ASSAY, AQUEOUS-MEDIA, ANTIMUTAGENIC ACTIVITIES, MUTAGENICITY ASSAY, BETA-AMINOKETONES, SOLVENT-FREE, 3-COMPONENT

Abstract

Direct-type catalytic Mannich reaction for the synthesis of -aminoketones from cyclohexanone, substituted aromatic amines and aromatic or hetero-aromatic aldehydes has been applied in water with bismuth triflate under ultrasound. Good yields of the expected -aminoketones were obtained from available substrates, at room temperature in 1-2 hours. This study was designed to evaluate the mutagenic and antimutagenic potential of synthesized -aminoketones compounds using Ames/Salmonella and Escherichia coli WP2 bacterial reverse mutation assay systems.