Ultrasonic synthesis, characterization of -aminoketones by bismuth(III) triflate and determination of antigenotoxic properties


Ozturkcan S. A. , TURHAN K. , TURGUT Z. , KARADAYI M., GÜLLÜCE M.

TOXICOLOGY AND INDUSTRIAL HEALTH, cilt.31, ss.911-919, 2015 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 31 Konu: 10
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1177/0748233713484649
  • Dergi Adı: TOXICOLOGY AND INDUSTRIAL HEALTH
  • Sayfa Sayısı: ss.911-919

Özet

Direct-type catalytic Mannich reaction for the synthesis of -aminoketones from cyclohexanone, substituted aromatic amines and aromatic or hetero-aromatic aldehydes has been applied in water with bismuth triflate under ultrasound. Good yields of the expected -aminoketones were obtained from available substrates, at room temperature in 1-2 hours. This study was designed to evaluate the mutagenic and antimutagenic potential of synthesized -aminoketones compounds using Ames/Salmonella and Escherichia coli WP2 bacterial reverse mutation assay systems.