CHEMICAL PAPERS, vol.67, no.6, pp.643-649, 2013 (Journal Indexed in SCI)
Article / Article
Title of Journal :
tandospirone, arylpiperazines, C-C coupling, hydroarylation, heterocycles, SUBSTITUTED TRICYCLIC IMIDES, DOPAMINE D3 RECEPTOR, UNSATURATED DICARBOXIMIDES, PHARMACOLOGICAL AGENTS, EPIBATIDINE, DERIVATIVES, CHEMISTRY, AFFINITY, NUCLEUS, AGONIST
Tandospirone (I), developed as an anxiolytic drug, is an aryl-piperazine compound that binds to both 5-HT1A and dopamine D4 receptors. Palladium-catalysed hydroarylation reactions of tandospirone analogues containing an oxygen bridge and 3-(trifluoromethyl)phenyl or 2,3-dichlorophenyl groups were studied in order to find a new stereoselective access to a series of new exo-aryl(hetaryl)-substituted derivatives with potential biological activity.