The structure of lactate dehydrogenase from Plasmodium falciparum reveals a new target for anti-malarial design
NATURE STRUCTURAL BIOLOGY, vol.3, no.11, pp.912-915, 1996 (SCI-Expanded, Scopus)
- Publication Type: Article / Letter
- Volume: 3 Issue: 11
- Publication Date: 1996
- Doi Number: 10.1038/nsb1196-912
- Journal Name: NATURE STRUCTURAL BIOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.912-915
- Yıldız Technical University Affiliated: No
Abstract
The crystal structure of Plasmodium falciparum lactate dehydrogenase reveals a surprising shift in the position of the NADH cofactor that explains the unusual biochemical properties of this enzyme. There is also a distinctive surface cleft adjacent to the NADH binding pocket that forms an attractive target for inhibitor design.