The structure of lactate dehydrogenase from Plasmodium falciparum reveals a new target for anti-malarial design


Dunn C., Banfield M., Barker J., Higham C., Moreton K., Turgut-Balik D. , et al.

NATURE STRUCTURAL BIOLOGY, cilt.3, ss.912-915, 1996 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 3 Konu: 11
  • Basım Tarihi: 1996
  • Doi Numarası: 10.1038/nsb1196-912
  • Dergi Adı: NATURE STRUCTURAL BIOLOGY
  • Sayfa Sayısı: ss.912-915

Özet

The crystal structure of Plasmodium falciparum lactate dehydrogenase reveals a surprising shift in the position of the NADH cofactor that explains the unusual biochemical properties of this enzyme. There is also a distinctive surface cleft adjacent to the NADH binding pocket that forms an attractive target for inhibitor design.