Current Strategies for the Regeneration of Skeletal Muscle Tissue

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ALARÇİN E., Bal-ozturk A., AVCI H., GHORBANPOOR H., DOĞAN GÜZEL F., AKPEK A., ...Daha Fazla

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, cilt.22, sa.11, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 22 Sayı: 11
  • Basım Tarihi: 2021
  • Doi Numarası: 10.3390/ijms22115929
  • Dergi Adı: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Anahtar Kelimeler: skeletal muscle cells, tissue engineering, hydrogels, scaffold topographies, MESENCHYMAL STEM-CELLS, MUSCULAR-DYSTROPHY PATIENT, BONE-MARROW, SATELLITE CELLS, VOLUMETRIC MUSCLE, MYOBLAST DIFFERENTIATION, STROMAL CELLS, IN-VITRO, MYOGENIC DIFFERENTIATION, REPAIR CONSTRUCT
  • Yıldız Teknik Üniversitesi Adresli: Hayır

Özet

Traumatic injuries, tumor resections, and degenerative diseases can damage skeletal muscle and lead to functional impairment and severe disability. Skeletal muscle regeneration is a complex process that depends on various cell types, signaling molecules, architectural cues, and physicochemical properties to be successful. To promote muscle repair and regeneration, various strategies for skeletal muscle tissue engineering have been developed in the last decades. However, there is still a high demand for the development of new methods and materials that promote skeletal muscle repair and functional regeneration to bring approaches closer to therapies in the clinic that structurally and functionally repair muscle. The combination of stem cells, biomaterials, and biomolecules is used to induce skeletal muscle regeneration. In this review, we provide an overview of different cell types used to treat skeletal muscle injury, highlight current strategies in biomaterial-based approaches, the importance of topography for the successful creation of functional striated muscle fibers, and discuss novel methods for muscle regeneration and challenges for their future clinical implementation.