The Influence of Functional Graphene on Photodynamic Effect With Singlet Oxygen Generation
Journal of Chemistry, cilt.2026, sa.1, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 2026 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.1155/joch/8045186
- Dergi Adı: Journal of Chemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Directory of Open Access Journals, Academic Search Ultimate (EBSCO), Materials Science & Engineering Collection (ProQuest), Technology Collection (ProQuest)
- Anahtar Kelimeler: cancer, graphene, photodynamic effect, singlet oxygen generation, thermal and chemical reduction
- Yıldız Teknik Üniversitesi Adresli: Evet
Özet
Advances in nanotechnology and nanoparticle production provide novel possibilities for enhancing photodynamic therapy’s effectiveness and selectivity. Recent advances in the synthesis and design of graphene-based nanocomposites have led to significant developments in the use of these materials for therapeutic and diagnostic purposes, establishing an emerging field of nanocancer diagnosis and therapy. The focus of this study is to demonstrate the photodynamic effects of graphene oxides (GOs) produced using the Hummer technique. This work utilized a top-down method for the first time to produce smaller GO particles in order to observe the photodynamic effect, which is different from previous research. The efficiency of the GO structure was characterized by atomic force microscopy (AFM), ultraviolet (UV–Vis) spectroscopy, Fourier-transform infrared (FT-IR) spectroscopy, zeta potential, and energy-dispersive X-ray analysis (EDX/EDS). Herein, we investigated the photoactivity of single-atomic–layered GO by examining its ability to generate singlet oxygen (1O2) under chemical and thermal reduction. We demonstrated that GO sonicated for 2 h showed excellent 1O2 production from GO with heat treatment at 50°C and 100°C. These findings suggest GO may be used as a photosensitizer (PS) agent in photodynamic therapy (PDT) cancer treatment. The incorporation of graphene-based materials into PDT has enormous promise for the development of focused, efficient, and customized cancer treatments, provided that the current state of research and the problems it presents are widely recognized.