Problems in Stem Cell Therapy for Cardiac Repair and Tissue Engineering Approaches Based on Graphene and Its Derivatives


ASLAN A. , Allahverdiyev A. , Bağırova M. , Abamor E. Ş.

CURRENT STEM CELL RESEARCH & THERAPY, vol.13, no.6, pp.447-457, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 13 Issue: 6
  • Publication Date: 2018
  • Doi Number: 10.2174/1574888x13666180510110055
  • Title of Journal : CURRENT STEM CELL RESEARCH & THERAPY
  • Page Numbers: pp.447-457
  • Keywords: Conductivity, coronary artery disease, graphene, stem cells, therapy, tissue engineering, SKELETAL MYOBLAST TRANSPLANTATION, ENDOTHELIAL PROGENITOR CELLS, RANDOMIZED PHASE-1 TRIAL, BONE-MARROW, MYOCARDIAL-INFARCTION, GROWTH-FACTORS, CARDIOMYOGENIC DIFFERENTIATION, ELECTROCHEMICAL REDUCTION, ANTIBACTERIAL ACTIVITY, INTERNATIONAL-SOCIETY

Abstract

Background: Today, coronary artery disease is still one of the most important causes of mortality despite advanced surgical methods, pharmacotherapies and organ transplantation. These treatment modalities are intended to prevent further progression of myocardial infarction and do not involve the repair of the damaged part. Therefore, stem cell therapy has emerged as a new approach for the treatment of coronary artery disease. However, there are some restrictions that limit the use of these cells for desired repair. The leading limitation is that newly formed cardiomyocytes do not provide electrical integrity with local cells.