Problems in Stem Cell Therapy for Cardiac Repair and Tissue Engineering Approaches Based on Graphene and Its Derivatives

ASLAN A., Allahverdiyev A., Bağırova M., Abamor E. Ş.

CURRENT STEM CELL RESEARCH & THERAPY, cilt.13, sa.6, ss.447-457, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 13 Sayı: 6
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1574888x13666180510110055
  • Dergi Adı: CURRENT STEM CELL RESEARCH & THERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.447-457
  • Anahtar Kelimeler: Conductivity, coronary artery disease, graphene, stem cells, therapy, tissue engineering, SKELETAL MYOBLAST TRANSPLANTATION, ENDOTHELIAL PROGENITOR CELLS, RANDOMIZED PHASE-1 TRIAL, BONE-MARROW, MYOCARDIAL-INFARCTION, GROWTH-FACTORS, CARDIOMYOGENIC DIFFERENTIATION, ELECTROCHEMICAL REDUCTION, ANTIBACTERIAL ACTIVITY, INTERNATIONAL-SOCIETY
  • Yıldız Teknik Üniversitesi Adresli: Evet

Özet

Background: Today, coronary artery disease is still one of the most important causes of mortality despite advanced surgical methods, pharmacotherapies and organ transplantation. These treatment modalities are intended to prevent further progression of myocardial infarction and do not involve the repair of the damaged part. Therefore, stem cell therapy has emerged as a new approach for the treatment of coronary artery disease. However, there are some restrictions that limit the use of these cells for desired repair. The leading limitation is that newly formed cardiomyocytes do not provide electrical integrity with local cells.