Preparation and optimization of biodegradable self-assembled PCL-PEG-PCL nano-sized micelles for drug delivery systems


Kocabay O. G. , İsmail O.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, vol.70, no.5, pp.328-337, 2021 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 70 Issue: 5
  • Publication Date: 2021
  • Doi Number: 10.1080/00914037.2020.1713784
  • Title of Journal : INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
  • Page Numbers: pp.328-337
  • Keywords: Poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone), polymeric micelles, nano-precipitation method, biodegradable, self-assembly, TRIBLOCK COPOLYMER, GOLD NANOPARTICLES, IN-VITRO, RELEASE, DOXORUBICIN, BIODISTRIBUTION, EFFICIENCY

Abstract

Biodegradable polymeric micelles have potential therapeutic applications; nevertheless, preparing micelles of a specific diameter and uniform size distribution is a challenge. Micelles were formed from the copolymer of poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) and the effect of PCEC molecular weight, PCL/PEG ratio, solvent-water miscibility, solvent concentration on particle size, polydispersity index and zeta potential of micelles were also investigated. The average particle sizes of the PCEC micelles ranged between 225-959 and 232-1211 nm for micelles prepared with acetone and dimethylformamide, respectively. The encapsulation efficiency is 78.98%. These results indicate that PCEC micelles can be used as drug carriers in controlled delivery systems.