INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, vol.70, no.5, pp.328-337, 2021 (SCI-Expanded)
Article / Article
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex, INSPEC
Poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone), polymeric micelles, nano-precipitation method, biodegradable, self-assembly, TRIBLOCK COPOLYMER, GOLD NANOPARTICLES, IN-VITRO, RELEASE, DOXORUBICIN, BIODISTRIBUTION, EFFICIENCY
Yıldız Technical University Affiliated:
Biodegradable polymeric micelles have potential therapeutic applications; nevertheless, preparing micelles of a specific diameter and uniform size distribution is a challenge. Micelles were formed from the copolymer of poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) and the effect of PCEC molecular weight, PCL/PEG ratio, solvent-water miscibility, solvent concentration on particle size, polydispersity index and zeta potential of micelles were also investigated. The average particle sizes of the PCEC micelles ranged between 225-959 and 232-1211 nm for micelles prepared with acetone and dimethylformamide, respectively. The encapsulation efficiency is 78.98%. These results indicate that PCEC micelles can be used as drug carriers in controlled delivery systems.