Sunset Yellow (SY), Carmoisine (C), Ponceau 4R (P), and Patent Blue V (PB) are synthetic organic dyes which are under governmental regulations all over the world because of their toxicity and carcinogenicity. In this study, a simple and fast analytical procedure was proposed for the simultaneous determination of food dyes (SY, C, P, and PB) in powder drinks by means the partial least-square treatment of spectrophotometric absorbance between 450 – 730 nm, taken at 10 nm intervals. The experimental calibration matrix was constructed with 27 samples. The concentration ranges considered were 2, 3, 4 mg . ml21 for SY, 7, 8, 9 mg . ml21 for C, 9, 10, 11 mg . ml21 for P, and 0.3, 0.4, 0.5 mg . ml21 for PB. The method was applied to the determination of dyes in different commercially available powder drinks. The results obtained by the application of the PLS-2 method were statistically compared with those obtained by an HPLC method using the F and t tests. Very similar values were found by two methods. No time consuming pretreatment was needed and this method also provides rapid, accurate and economical analysis of these colors.