Current Approaches in Development of Immunotherapeutic Vaccines for Breast Cancer

ALLAHVERDİYEV A., Tarı G., BAĞIROVA M., ABAMOR E. Ş.

JOURNAL OF BREAST CANCER, vol.21, no.4, pp.343-353, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 21 Issue: 4
  • Publication Date: 2018
  • Doi Number: 10.4048/jbc.2018.21.e47
  • Journal Name: JOURNAL OF BREAST CANCER
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.343-353
  • Keywords: Breast neoplasms, Immunology, Immunotherapy, Vaccines, VIRUS-LIKE PARTICLES, DENDRITIC CELLS, HER2/NEU-DERIVED PEPTIDE, ACID NANOPARTICLES, TUMOR-GROWTH, IN-VITRO, PHASE-I, RESPONSES, VACCINATION, MICE
  • Yıldız Technical University Affiliated: Yes

Abstract

Cancer is the leading cause of death worldwide. In developed as well as developing countries, breast cancer is the most common cancer found among women. Currently, treatment of breast cancer consists mainly of surgery, chemotherapy, hormone therapy, and radiotherapy. In recent years, because of increased understanding of the therapeutic potential of immunotherapy in cancer prevention, cancer vaccines have gained importance. Here, we review various immunotherapeutic breast cancer vaccines including peptide-based vaccines, whole tumor cell vaccines, gene-based vaccines, and dendritic cell vaccines. We also discuss novel nanotechnology-based approaches to improving breast cancer vaccine efficiency.