Akademik Veri Yönetim Sistemi
1ˢᵗ International Karatekin Science and Technology Conference, Çankırı, Türkiye, 1 - 03 Eylül 2022, ss.165-168
The aim of the given study is the formation as well as the development of patches of Donepezil HCl, which is used in
the treatment of Alzheimer's disease (AD). AD is a progressive brain disease and the leading cause of dementia in the
elderly. Conventional treatments for the management of AD have all been given orally, thus Donepezil is commonly
used as an oral tablet, although a transdermal patch may offer advantages as an alternate therapyTransdermal medication
administration for Alzheimer's disease has been shown to enhance patient compliance through reduced dosage frequency,
improve bioavailability, reduce undesirable side effects, and make it easier to attain optimal levels. Furthermore, it
promotes patient compliance in older patients since the patient does not have to remember to take their prescription or
bring tablets for further administration later in the day. The transdermal approach provides various advantages over the
oral route, including the ability to maintain sustained therapeutic plasma. In the present work, matrix-type transdermal
patches of Donepezil HCl were prepared using the solvent casting method. Formulations were synthesized using
Hydroxyethyl-cellulose (HEC), Poly (acrylic acid sodium salt) and Poly (acrylic acid) as polymers -individually- with
varying degrees of hydrophilicity with Gelatin as a jellify to provide flexibility and Glycerol as a plasticizer additive, and
to improve drug release by increasing permeability.