PRODUCING AFLIBERCEPT LOADED POLY (LACTIC-co-GLYCOLIC ACID) [PLGA] NANOPARTICLES AS A NEW OCULAR DRUG DELIVERY SYSTEM AND ITS CHALLENGES


Karagoz I. K. , Allahverdiyev A., Demircioglu A., ABAMOR E. Ş. , Dinparvar S., Bagirova M.

FRESENIUS ENVIRONMENTAL BULLETIN, vol.30, no.2, pp.1481-1493, 2021 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 2
  • Publication Date: 2021
  • Journal Name: FRESENIUS ENVIRONMENTAL BULLETIN
  • Journal Indexes: Science Citation Index Expanded, Aerospace Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, Environment Index, Geobase, Greenfile, Metadex, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Page Numbers: pp.1481-1493
  • Keywords: Anti -VEGF, Drug Delivery, Nanoparticle, Retina, INTRAVITREAL BEVACIZUMAB AVASTIN, VEGF-TRAP, MACULAR DEGENERATION, INTRAOCULAR PHARMACOKINETICS, RANIBIZUMAB, INJECTION, TOXICITY, SINGLE, EYE, NEOVASCULARIZATION

Abstract

The aim of the present study is to develop a new drug delivery system with the aid of nanomedicine for aflibercept molecule and to evaluate optimization, characterization, in vitro drug release profile and toxicity on human retinal pigment epithelial (ARPE-19) and human retinal endothelial cell (HREC) lines.