PRODUCING AFLIBERCEPT LOADED POLY (LACTIC-co-GLYCOLIC ACID) [PLGA] NANOPARTICLES AS A NEW OCULAR DRUG DELIVERY SYSTEM AND ITS CHALLENGES
FRESENIUS ENVIRONMENTAL BULLETIN, vol.30, no.2, pp.1481-1493, 2021 (SCI-Expanded)
- Publication Type: Article / Article
- Volume: 30 Issue: 2
- Publication Date: 2021
- Journal Name: FRESENIUS ENVIRONMENTAL BULLETIN
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Aerospace Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, Environment Index, Geobase, Greenfile, Metadex, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
- Page Numbers: pp.1481-1493
- Keywords: Anti -VEGF, Drug Delivery, Nanoparticle, Retina, INTRAVITREAL BEVACIZUMAB AVASTIN, VEGF-TRAP, MACULAR DEGENERATION, INTRAOCULAR PHARMACOKINETICS, RANIBIZUMAB, INJECTION, TOXICITY, SINGLE, EYE, NEOVASCULARIZATION
- Yıldız Technical University Affiliated: Yes
Abstract
The aim of the present study is to develop a new drug delivery system with the aid of nanomedicine for aflibercept molecule and to evaluate optimization, characterization, in vitro drug release profile and toxicity on human retinal pigment epithelial (ARPE-19) and human retinal endothelial cell (HREC) lines.