PRODUCING AFLIBERCEPT LOADED POLY (LACTIC-co-GLYCOLIC ACID) [PLGA] NANOPARTICLES AS A NEW OCULAR DRUG DELIVERY SYSTEM AND ITS CHALLENGES


Karagoz I. K., Allahverdiyev A., Demircioglu A., ABAMOR E. Ş., Dinparvar S., Bagirova M.

FRESENIUS ENVIRONMENTAL BULLETIN, cilt.30, sa.2, ss.1481-1493, 2021 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 2
  • Basım Tarihi: 2021
  • Dergi Adı: FRESENIUS ENVIRONMENTAL BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Aerospace Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, Environment Index, Geobase, Greenfile, Metadex, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.1481-1493
  • Anahtar Kelimeler: Anti -VEGF, Drug Delivery, Nanoparticle, Retina, INTRAVITREAL BEVACIZUMAB AVASTIN, VEGF-TRAP, MACULAR DEGENERATION, INTRAOCULAR PHARMACOKINETICS, RANIBIZUMAB, INJECTION, TOXICITY, SINGLE, EYE, NEOVASCULARIZATION
  • Yıldız Teknik Üniversitesi Adresli: Evet

Özet

The aim of the present study is to develop a new drug delivery system with the aid of nanomedicine for aflibercept molecule and to evaluate optimization, characterization, in vitro drug release profile and toxicity on human retinal pigment epithelial (ARPE-19) and human retinal endothelial cell (HREC) lines.