PRODUCING AFLIBERCEPT LOADED POLY (LACTIC-co-GLYCOLIC ACID) [PLGA] NANOPARTICLES AS A NEW OCULAR DRUG DELIVERY SYSTEM AND ITS CHALLENGES


Karagoz I. K. , Allahverdiyev A. , Demircioglu A., ABAMOR E. Ş. , Dinparvar S., Bagirova M.

FRESENIUS ENVIRONMENTAL BULLETIN, vol.30, no.2, pp.1481-1493, 2021 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 2
  • Publication Date: 2021
  • Title of Journal : FRESENIUS ENVIRONMENTAL BULLETIN
  • Page Numbers: pp.1481-1493

Abstract

The aim of the present study is to develop a new drug delivery system with the aid of nanomedicine for aflibercept molecule and to evaluate optimization, characterization, in vitro drug release profile and toxicity on human retinal pigment epithelial (ARPE-19) and human retinal endothelial cell (HREC) lines.