SIMULTANEOUS DETERMINATION OF ACETAMINOPHEN AND CAFFEINE IN TABLET PREPARATIONS BY PARTIAL LEAST-SQUARES MULTIVARIATE SPECTROPHOTOMETRIC CALIBRATION

BOZDOGAN A. E. , ACAR A., KUNT G.

TALANTA, vol.39, no.8, pp.977-979, 1992 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 8
  • Publication Date: 1992
  • Doi Number: 10.1016/0039-9140(92)80281-h
  • Title of Journal : TALANTA
  • Page Numbers: pp.977-979

Abstract

The use of partial least-squares spectrophotometric calibration for the simultaneous determination of analgesic tablets in a multicomponent formulation is presented. This method is applied to the determination of acetaminophen and caffeine in tablet preparations. The results show that these components in a molar ratio of about 21:1 in tablets have been determined simultaneously with high precision.