SIMULTANEOUS DETERMINATION OF ACETAMINOPHEN AND CAFFEINE IN TABLET PREPARATIONS BY PARTIAL LEAST-SQUARES MULTIVARIATE SPECTROPHOTOMETRIC CALIBRATION

BOZDOGAN, Abdürrezzak; ACAR, AM; KUNT, Gönül

doi:10.1016/0039-9140(92)80281-h

SIMULTANEOUS DETERMINATION OF ACETAMINOPHEN AND CAFFEINE IN TABLET PREPARATIONS BY PARTIAL LEAST-SQUARES MULTIVARIATE SPECTROPHOTOMETRIC CALIBRATION

Atıf İçin Kopyala

BOZDOGAN A. E. , ACAR A., KUNT G.

TALANTA, cilt.39, ss.977-979, 1992 (SCI İndekslerine Giren Dergi)

Cilt numarası: 39 Konu: 8
Basım Tarihi: 1992
Doi Numarası: 10.1016/0039-9140(92)80281-h
Dergi Adı: TALANTA
Sayfa Sayısı: ss.977-979

Özet

The use of partial least-squares spectrophotometric calibration for the simultaneous determination of analgesic tablets in a multicomponent formulation is presented. This method is applied to the determination of acetaminophen and caffeine in tablet preparations. The results show that these components in a molar ratio of about 21:1 in tablets have been determined simultaneously with high precision.