SIMULTANEOUS DETERMINATION OF ACETAMINOPHEN AND CAFFEINE IN TABLET PREPARATIONS BY PARTIAL LEAST-SQUARES MULTIVARIATE SPECTROPHOTOMETRIC CALIBRATION
TALANTA, vol.39, no.8, pp.977-979, 1992 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 39 Issue: 8
- Publication Date: 1992
- Doi Number: 10.1016/0039-9140(92)80281-h
- Journal Name: TALANTA
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.977-979
- Yıldız Technical University Affiliated: Yes
Abstract
The use of partial least-squares spectrophotometric calibration for the simultaneous determination of analgesic tablets in a multicomponent formulation is presented. This method is applied to the determination of acetaminophen and caffeine in tablet preparations. The results show that these components in a molar ratio of about 21:1 in tablets have been determined simultaneously with high precision.