The effect of photoactivated Riboflavin on primary dentin remineralizatıon: a pilot study

Muratoglu B., Aydınoglu A., Yoruc A. B., Kargul B.

Journal of research in pharmacy (online), vol.27, no.3, pp.1015-1020, 2023 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 3
  • Publication Date: 2023
  • Doi Number: 10.29228/jrp.395
  • Journal Name: Journal of research in pharmacy (online)
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1015-1020
  • Yıldız Technical University Affiliated: Yes


This study aims to evaluate the effect of photoactivated riboflavin (RF) on demineralized dentin of the primary molars. Fifty primary molars were selected for the study. The specimens were divided into five groups based upon the remineralization of dentin with photoactivated 0.1% RF. In Group I (n = 20), dentin remineralization was done with photoactivated 0.1% RF for 30 s, in Group II photoactivated 0.1% RF for 60 s. In Group III (positive control), dentin remineralization was done with remineralization solution. In Group IV (negatif control) only used distilled water. Surface Microhardness analysis (SMH) was evaluated using Vickers microhardness tester (EmcoTest, Duravision 20 G5, Vickers, DV250539, Mechanical Instrument Hardness Tester, Germany). D-Light Pro offers a unique Detection Mode based on near-UV light only. Data was analyzed with One way ANOVA test, Tukey’s test, Student’s t-test, Mann Whitney test, Dunn test and Kruskal-Wallis test were used. The SMH values of test groups were significantly higher than those of the negative control group (p = 0.01). The %SMHR values of Group III was significantly higher than Group I and II. The comparison between groups showed no statistically significant differences in %SMHR among Groups I with Group II and IV (p> 0.05). According to the findings of this study; we concluded that Riboflavin have a significant effect on demineralizated dentine. The remineralization effect of riboflavin on demineralized dentin needs to be relevant to further studies.