Synthesis, Antibacterial and Cytotoxic Activities of New Thiazole Based Pyrrolidine Derivatives
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY, vol.11, no.4, pp.12178-12185, 2021 (ESCI, Scopus)
- Publication Type: Article / Article
- Volume: 11 Issue: 4
- Publication Date: 2021
- Doi Number: 10.33263/briac114.1217812185
- Journal Name: BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
- Page Numbers: pp.12178-12185
- Open Archive Collection: AVESIS Open Access Collection
- Yıldız Technical University Affiliated: Yes
Abstract
In this study, some thiazole-based pyrrolidine derivatives were synthesized, characterized by FT-IR and H-1 NMR spectroscopic techniques, and evaluated as potential antibacterial agents. Their antibacterial activities were evaluated by broth microdilution method and expressed as minimum inhibitory concentration; against Escherichia coli, Salmonella typhimurium, Bacillus cereus, and Staphylococcus aureus. Cytotoxicity studies of synthesized compounds were also conducted to minimize the toxic effects on healthy mammalian cells. From synthesized compounds, 4-F-phenyl derivative compound (11) has been found to inhibit Gram-positive bacteria with minimum toxicity selectively.