Synthesis, Antibacterial and Cytotoxic Activities of New Thiazole Based Pyrrolidine Derivatives


KOCABAŞ E., SARIGÜNEY A. B. , Erci F., ÇAKIR KOÇ R. , Kocabas H. O. , TORLAK E., ...More

BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY, vol.11, no.4, pp.12178-12185, 2021 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.33263/briac114.1217812185
  • Title of Journal : BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
  • Page Numbers: pp.12178-12185

Abstract

In this study, some thiazole-based pyrrolidine derivatives were synthesized, characterized by FT-IR and H-1 NMR spectroscopic techniques, and evaluated as potential antibacterial agents. Their antibacterial activities were evaluated by broth microdilution method and expressed as minimum inhibitory concentration; against Escherichia coli, Salmonella typhimurium, Bacillus cereus, and Staphylococcus aureus. Cytotoxicity studies of synthesized compounds were also conducted to minimize the toxic effects on healthy mammalian cells. From synthesized compounds, 4-F-phenyl derivative compound (11) has been found to inhibit Gram-positive bacteria with minimum toxicity selectively.