Synthesis, Antibacterial and Cytotoxic Activities of New Thiazole Based Pyrrolidine Derivatives


KOCABAŞ E., SARIGÜNEY A. B. , Erci F., ÇAKIR KOÇ R. , Kocabas H. O. , TORLAK E., ...Daha Fazla

BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY, cilt.11, sa.4, ss.12178-12185, 2021 (ESCI İndekslerine Giren Dergi) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Konu: 4
  • Basım Tarihi: 2021
  • Doi Numarası: 10.33263/briac114.1217812185
  • Dergi Adı: BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
  • Sayfa Sayıları: ss.12178-12185

Özet

In this study, some thiazole-based pyrrolidine derivatives were synthesized, characterized by FT-IR and H-1 NMR spectroscopic techniques, and evaluated as potential antibacterial agents. Their antibacterial activities were evaluated by broth microdilution method and expressed as minimum inhibitory concentration; against Escherichia coli, Salmonella typhimurium, Bacillus cereus, and Staphylococcus aureus. Cytotoxicity studies of synthesized compounds were also conducted to minimize the toxic effects on healthy mammalian cells. From synthesized compounds, 4-F-phenyl derivative compound (11) has been found to inhibit Gram-positive bacteria with minimum toxicity selectively.