Asst. Prof. Çiğdem BİLEN

Publication Network

Articles 34

1. Inhibition effects of amino acids on polyphenol oxidase activity isolated from medlar fruit

Özdemir E., BİLEN Ç., KARAKUŞ E.

Biotechnology Letters , vol.48, no.1, 2026 (SCI-Expanded, Scopus)

2. Affinity chromatography studies for mespilus germanica L. polyphenol oxidase

Cavdar A., KARAKUŞ E., BİLEN Ç.

Biotechnology Letters , vol.47, no.6, 2025 (SCI-Expanded, Scopus)

3. A New Affinity Gel Synthesized for Phenylalanine Ammonia Lyase Isolated from Red Clover (Trifolium pratense L.) Leaf and an Investigation into Its Kinetic Properties †

Toksöz Y. S., BİLEN Ç., KARAKUŞ E.

Separations , vol.12, no.9, 2025 (SCI-Expanded, Scopus)

4. Paraoxonase Enzyme Activity and Determination of Phenotypic Polymorphism in Patients with Acne Vulgaris

Can İ., BİLEN Ç., Gençer N., Öztürk S., Kılıç A.

Turkish Journal of Dermatology , vol.19, no.2, pp.91-96, 2025 (ESCI, Scopus)

5. Purification and characterization of avocado (Persea americana) polyphenol oxidase by affinity chromatography

Alishah M. M., Yildiz S., BİLEN Ç., KARAKUŞ E.

PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY , vol.53, no.1, pp.40-53, 2023 (SCI-Expanded, Scopus)

6. Purification of damson plum polyphenol oxidase by affinity chromatography and investigation of metal effects on enzyme activity

Yildiz S., BİLEN Ç., KARAKUŞ E.

PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY , vol.52, no.9, pp.1019-1034, 2022 (SCI-Expanded, Scopus)

7. Development of a fluorometric measurement system used in biological samples upon the determination of iron (II) metal ion

Toksoz Y. S., ÖZYİĞİT İ. E., BİLEN Ç., ARSU N., KARAKUŞ E.

PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY , vol.51, no.4, pp.361-374, 2021 (SCI-Expanded, Scopus)

8. A novel fluorometric measurement system based on triple complex for mercury (II) determination

Toksöz Y. S., ÖZYİĞİT İ. E., BİLEN Ç., ARSU N., KARAKUŞ E.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY , vol.248, 2021 (SCI-Expanded, Scopus) Sustainable Development

9. Paraoxonase Activity and Phenotype Distribution in Patients with Chronic Obstructive Pulmonary Disease

Sarıoğlu N., Bilen Ç., Çevik C., Gençer N.

The Eurasian Journal of Medicine , no.1, pp.1-14, 2019 (Peer-Reviewed Journal)

10. Synthesis, Biological Activity and Structure-Activity Relationship of Novel Diphenylurea Derivatives Containing Tetrahydroquinoline as Carbonic Anhydrase I and II Inhibitors

Atahan A., Gencer N., Bilen C., Yavuz E., Genc H., Sonmez F., et al.

CHEMISTRYSELECT , vol.3, no.2, pp.529-534, 2018 (SCI-Expanded, Scopus)

11. The effects of ex vivo ozone treatment on human erythrocyte carbonic anhydrase enzyme

Erken G., Erken H. A., Bilen C., Gencer N.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY , vol.124, pp.171-174, 2018 (SCI-Expanded, Scopus) Sustainable Development

12. Synthesis and Biological Evaluation of New 4-Thiazolidinone Derivatives as Carbonic Anhydrase Inhibitors

Genc H., Ceken B., Bilen C., Sackes Z., Gencer N., Arslan O.

LETTERS IN ORGANIC CHEMISTRY , vol.14, no.2, pp.80-85, 2017 (SCI-Expanded, Scopus)

13. Synthesis and carbonic anhydrase inhibitory properties of new spiroindoline-substituted sulphonamide compounds

Gulec O., Arslan M., Gencer N., Ergun A., Bilen C., Arslan O.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY , vol.123, no.5, pp.306-312, 2017 (SCI-Expanded, Scopus)

14. Synthesis and evaluation of sulfonamide-bearing thiazole as carbonic anhydrase isoforms hCA I and hCA II

Kilicaslan S., Arslan M., Ruya Z., Bilen C., Ergun A., Gencer N., et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY , vol.31, no.6, pp.1300-1305, 2016 (SCI-Expanded, Scopus)

15. Is the COPD assessment test (CAT) effective in demonstrating the systemic inflammation and other components in COPD?

Sarıoğlu N., Hişmioğulları A. A., Bilen Ç., Erel F.

REVISTA PORTUGUESA DE PNEUMOLOGIA , vol.22, pp.11-17, 2016 (SCI-Expanded, Scopus)

16. Coumarin or benzoxazinone based novel carbonic anhydrase inhibitors: synthesis, molecular docking and anticonvulsant studies

KARATAŞ M. O., USLU H., SARI S., Alagoz M. A., KARAKURT A., ALICI B., et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY , vol.31, no.5, pp.760-772, 2016 (SCI-Expanded, Scopus)

17. Synthesis, antioxidant and carbonic anhydrase I and II inhibitory activities of novel sulphonamide-substituted coumarylthiazole derivatives

KURT B. Z., Sonmez F., Bilen C., Ergun A., Gencer N., Arslan O., et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY , vol.31, no.6, pp.991-998, 2016 (SCI-Expanded, Scopus)

18. Purification of Alkaline Phosphatase from Bovine Milk and Investigation of Inhibitory Effects Of Some Veterinary Drugs on Enzyme Activity

Bilen Ç., Gencer N., Arslan O.

Hacettepe Journal of Biology and Chemistry , vol.43, no.3, pp.195-203, 2015 (Scopus, TRDizin)

19. In vitro effects of estrogen and progesterone containing drugs on human erythrocyte carbonic anhydrase I and II isozymes in women smokers and nonsmokers

Taskin M. I., Bilen C., Ergun A., Gencer N., Inceboz U.

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION , vol.78, no.9, pp.513-519, 2015 (SCI-Expanded, Scopus) Sustainable Development

20. Synthesis and evaluation of new phthalazine substituted beta-lactam derivatives as carbonic anhydrase inhibitors

Berber N., Arslan M., Bilen C., Sackes Z., Gencer N., Arslan O.

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY , vol.41, no.4, pp.414-420, 2015 (SCI-Expanded, Scopus)

21. Synthesis and evaluation of N-heteroarylsubstituted triazolosulfonamides as carbonic anhydrase inhibitors

Balci A., Arslan M., NIXHA A. R., Bilen C., Ergun A., Gencer N.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY , vol.30, no.3, pp.377-382, 2015 (SCI-Expanded, Scopus)

22. Coumarin or benzoxazinone bearing benzimidazolium and bis(benzimidazolium) salts; involvement in transfer hydrogenation of acetophenone derivatives and hCA inhibition

KARATAS M. O., Dayan S., Kayacı N., BİLEN Ç., Yavuz E., Gencer N., et al.

Mediterranean Journal of Chemistry , vol.4, pp.252-260, 2015 (Peer-Reviewed Journal)

23. The effects of bronchodilator drugs and antibiotics used for respiratory infection on human erythrocyte carbonic anhydrase I and II isozymes

Sarioglu N., Bilen C., Sackes Z., Gencer N.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY , vol.121, no.2, pp.56-61, 2015 (SCI-Expanded, Scopus)

24. INHIBITION OF CARBONIC ANHYDRASE I AND II WITH TOTAL ANTHOCYANINS EXTRACTED FROM SWEET CHERRY CULTIVARS

Demir T., Gunesli Z., Sonmez F., Bilen C., Yavuz E., Gencer N.

Environmental Engineering and Management Journal , vol.14, no.4, pp.935-941, 2015 (SCI-Expanded, Scopus)

25. Synthesis, characterization and tyrosinase inhibitory properties of benzimidazole derivatives

KARATAŞ M. O., ALICI B., Cetinkaya E., Bilen C., Gencer N., Arslan O.

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY , vol.40, no.4, pp.461-466, 2014 (SCI-Expanded, Scopus)

26. The effects of antiepileptic drugs on human erythrocyte carbonic anhydrase I and II isozymes

Koç E. R., ERKEN G., BİLEN Ç., SACKES Z., GENCER N.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY , no.120, pp.131-135, 2014 (SCI-Expanded, Scopus)

27. Antipsychotic agents screened as human carbonic anhydrase I and II inhibitors

Erzengin M., Bilen C., Ergun A., Gencer N.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY , vol.120, no.1, pp.29-33, 2014 (SCI-Expanded, Scopus)

28. Synthesis and carbonic anhydrase inhibitory properties of 1,3-dicarbonyl derivatives of methylaminobenzene-sulfonamide

Demirci T., Arslan M., Bilen C., Demir D., Gencer N., Arslan O.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY , vol.29, no.1, pp.132-136, 2014 (SCI-Expanded, Scopus)

29. In vitro inhibition effect and structure-activity relationships of some saccharin derivatives on erythrocyte carbonic anhydrase I and II

Sonmez F., Bilen C., Sumersan S., Gencer N., Isik S., Arslan O., et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY , vol.29, no.1, pp.118-123, 2014 (SCI-Expanded, Scopus)

30. Synthesis and In Vitro Inhibition Effect of New Pyrido[2,3-d] pyrimidine Derivatives on Erythrocyte Carbonic Anhydrase I and II

Kuday H., Sonmez F., Bilen C., Yavuz E., Gencer N., Kucukislamoglu M.

BIOMED RESEARCH INTERNATIONAL , 2014 (SCI-Expanded, Scopus)

31. In vitro inhibition effect of some chalcones on erythrocyte carbonic anhydrase I and II

Gencer N., Bilen C., Demir D., Atahan A., Ceylan M., Kucukislamoglu M.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY , vol.41, no.6, pp.384-388, 2013 (SCI-Expanded, Scopus)

32. Extraction and Biological Activity of Total Anthocyanins from Sweet Cherry Cultivars as Polyphenol Oxidase Inhibitors

Demir T., Sönmez F., BİLEN Ç., Gencer N.

JOURNAL OF FOOD AGRICULTURE & ENVIRONMENT , vol.11, pp.572-575, 2013 (Peer-Reviewed Journal)

33. Investigation of heavy metal effects on immobilized paraoxanase by glutaraldehyde

Bilen Ç., Beyaztas S., Arslan O., Guler O. O.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY , vol.28, pp.440-446, 2013 (SCI-Expanded, Scopus)

34. Synthesis and Evaluation of New Phthalazine Urea and Thiourea Derivatives as Carbonic Anhydrase Inhibitors

Berber N., Arslan M., Yavuz E., Bilen C., Gencer N.

JOURNAL OF CHEMISTRY , 2013 (SCI-Expanded, Scopus)

Papers Presented at Peer-Reviewed Scientific Conferences 31

1. Purification and Characterization of Phenylalanine Ammonia Lyase from Leaf and Stalk Regions of Celery Plant by Affinity Chromatography

Özdemir S., Bilen Ç., Karakuş E.

International Yildirim Bayezid Scientific Research and Innovation Symposıum-I, Bursa, Turkey, 9 - 10 May 2025, pp.272-274, (Summary Text)

2. Purification and Characterization of Phenylalanine Ammonia Lyase from Celery Root and Investigation of the Effects of Some Metals on Enzyme Activity

Ermiş E., Bilen Ç., Karakuş E.

International Yildirim Bayezid Scientific Research and Innovation Symposıum-I, Bursa, Turkey, 9 - 10 May 2025, pp.232-234, (Summary Text)

3. Purification of Phenylalanine Ammonia Lyase Enzyme from Some Plants that Leaves are Consumed in Daily Life and Investigation of the Effects of Earth Metals on Optimum Enzyme Activity

Alak Z. G., Bilen Ç., Karakuş E.

Cukurova 13th International Scientific Researches Conference, Adana, Turkey, 1 - 03 September 2024, pp.165-167, (Summary Text)

4. PURIFICATION OF PHENYLALANINE AMMONIUM LYASE ENZYME FROM CLOVER LEAF AND DETERMINATION OF ITS KINETIC PROPERTIES

Toksöz Y. S., Bilen Ç., Karakuş E.

12th Aegean Analytical Chemistry Days, İstanbul, Turkey, 19 - 22 October 2023, pp.79-80, (Summary Text)

5. PURIFICATION OF POLYPHENOL OXIDASE ENZYME FROM AVOCADO BY AFFINITY CHROMATOGRAPHY

Moeini Alishah M., Bilen Ç., Karakuş E.

12th Agean Analytical Chemistry Congress, İstanbul, Turkey, 19 - 22 October 2023, pp.81, (Summary Text)

6. Purification and Characterization of Medlar (Mespilus germanica) Polyphenol Oxıdase Enzyme

Çavdar A., Bilen Ç., Karakuş E.

International Congress on Life, Social, Health and Sports Sciences in a Changing World, İzmir, Turkey, 24 - 26 September 2022, pp.182, (Summary Text)

7. Investigation of Inhibition Effects of Amino Acids on the Activity of Medlar (Mespilus germanica) Polyphenol Oxidase Enzyme

Özdemir E., Çavdar A., Bilen Ç., Karakuş E.

7th International Congress on Life, Social, Health and Sports Sciences in a Changing World, İzmir, Turkey, 24 - 26 September 2022, pp.228-229, (Summary Text)

8. Purification and Characterization of Polyphenol Oxidase Enzyme from Damson Plum (Prunus Insititia)

Yıldız S., Bilen Ç., Karakuş E.

3rd INTERNATIONAL CONGRESS on ANALYTICAL and BIOANALYTICAL CHEMISTRY, 22 - 26 March 2021, no.38, pp.95, (Summary Text)

9. Biyolojik Örneklerde Kullanılacak Florimetrik Metal Tayini Ölçüm Sistemi Geliştirilmesi

Toksöz Y. S., Özyiğit İ. E., Bilen Ç., Arsu N., Karakuş E.

31. Ulusal Kimya Kongresi, İstanbul, Turkey, 10 - 13 September 2019, pp.370, (Summary Text)

10. Bazı Metallerin TXSCH2COOH - BSA Kompleksi ile Etkileşiminin Floresans Emisyon Spektroskopi Yöntemi ile İncelenmesi

Toksöz Y. S., Özyiğit İ. E., Bilen Ç., Karakuş E.

III. Uluslararası AVRASYA Multidisipliner Çalışmalar Kongresi, Gaziantep, Turkey, 4 - 07 April 2019, pp.4, (Summary Text)

11. Synthesis and evaluation of sulfonamide-bearing thiazoles as Carbonic Anhydrase Inhibitors, poster sunum (P-21)

Isık S., Kılıcaslan S., Arslan M., Bilen Ç., Ergun A., Gencer N., et al.

New Trends in Carbonic Anhydrases’ Research, Florence University, Montecatini Terme, Florence, Italy, 25 May 2017, pp.82, (Summary Text)

12. Coumarin or benzoxazinone bearing benzimidazolium and bis(benzimidazolium) salts as hCA Inhibitiors, poster sunum (P-13)

Çarıkçı S., Gencer N., Arslan O., Karatas M. O., Alıcı B., Bilen Ç.

New Trends in Carbonic Anhydrases’ Research, Florence University, Montecatini Terme, Florence, Italy, 25 May 2017, pp.69, (Summary Text)

13. Evaluation Of Sulfonamide-Bearing Thiazole As Carbonic Anhydrase Inhibitors, poster sunum (P-0097)

Ergun A., Gencer N., Arslan O., Bilen Ç., Kılıcaslan S., Arslan M.

IVEK 3rd International Convention of Pharmaceuticals and Pharmacies / 3. Uluslararası İlaç ve Eczacılık Kongresi, İstanbul, Turkey, 26 April 2017, pp.245, (Summary Text)

14. "Synthesis, antioxidant and carbonic anhydrase I and II inhibitory activities of novel sulphonamide-substituted coumarylthiazole derivatives", poster sunum (P-0090)

Ergun A., Gencer N., Arslan O., Sonmez F., Kurt B. Z., Bilen Ç., et al.

IVEK 3rd International Convention of Pharmaceuticals and Pharmacies, İstanbul, Turkey, 26 April 2017, pp.238, (Summary Text)

15. Yeni Pirido [2,3-d] Pirimidin Türevlerinin Sentezi ve Eritrosit Karbonik Anhidraz I ve II İzoenzimleri Üzerine in vitro İnhibisyon Etkilerinin İncelenmesi, poster sunum (P-32)

Kuday H., Sonmez F., Bilen Ç., Yavuz E., Gencer N., Arslan O.

10. Ulusal Afinite Teknikleri Kongresi, Balıkesir, Turkey, 26 May 2016, pp.53, (Summary Text)

16. Alkalen Fosfatazın Saflaştırılması ve Bazı ilaçlara Karşı Afinitesinin Araştırılması, sözlü sunum (S-10)

Bilen Ç., Gencer N., Arslan O.

10. Ulusal Afinite Teknikleri Kongresi, Balıkesir, Turkey, 26 May 2016, pp.10, (Summary Text)

17. New Lactam Derivatives as Carbonic Anhydrase Inhibitors, poster sunum (P-123)

Sackes Z., Berber N., Arslan M., Bilen Ç., Gencer N., Arslan O.

International Multidisciplinary Symposium on Drug Research & Development, Faculty of Pharmacy, Anadolu University & Society of Researchers in Pharmacy and Medicine, Eskişehir, Turkey, 15 October 2015, pp.193, (Summary Text)

18. Ex Vivo Ozon Uygulamasının Eritrosit Karbonikanhidraz Enzimi Üzerindeki Etkisi, Türk Fizyolojik Bilimler Derneği, poster sunum (PC-166)

Erken G., Erken H. A., Bilen Ç., Gencer N.

41. Ulusal Fizyoloji Kongresi, Çanakkale Onsekiz Mart Üniversitesi, Çanakkale, Turkey, 09 September 2015, pp.207, (Summary Text) Sustainable Development

19. Östrojen ve Progesteron İçeren İlaçların Sigara İçen ve İçmeyen Kadınlarda Eritrosit Karbonik Anhidrazı I ve II Enzimi Üzerine İnvitro Etkileri, poster sunum (P-263)

Taskın M. I., Bilen Ç., Ergun A., Gencer N., İnceboz Ü.

13. Ulusal Jinekoloji ve Obstetrik Kongresi, Kaya Palazzo Golf Resort, Belek, Antalya, Turkey, 11 May 2015, pp.386-387, (Summary Text)

20. Inhibition of Carbonic Anhydrase I and II with Total Anthocyanins Extracted From Sweet Cherry Cultivars, (B-15 sf-158)

Sonmez F., Guneslı Z., Demır T., Bilen Ç., Yavuz E., Gencer N.

14th International Nutrition&Diagnostics Conference, Prague/Czech Republich, Praha, Czech Republic, 02 September 2014, pp.158, (Summary Text)

21. In Vitro Inhibition of Carbonic Anhydrase I and II by Some New Thiazetidinone Derivatives, poster sunum (P-76) Bahçeşehir University

Genc H., Ceken B., Zengın M., Gencer N., Bilen Ç., Sackes Z., et al.

2nd International BAU-Drug Design Symposium-Novel Methods and Emerging Targets in Drug Discovery & Patented Drug Development, İstanbul, Turkey, 17 April 2014, pp.158-159, (Summary Text)